Performance characteristics of seven automated CA125 assays

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Publication Type Manuscript
School or College School of Medicine
Department Pathology
Program ARUP Institute for Clinical and Experimental Pathology
Creator Mongia, Shella K.; Rawlins, Mindy, L.; Owen, William E.; Roberts, William L.
Title Performance characteristics of seven automated CA125 assays
Date 2005-08-29
Description Author manuscript. Cancer antigen 125 (CA125) is a high molecular mass glycoprotien, which is used as tumor marker to monitor disease progression, response to therapy and in early detection of recurrence after treatment for ovarian cancer. The Access 2, ADVIA Centaur, ARCHITECT i2000, AxSYM, Elecsys 2010, IMMULITE 2000, and VITROS ECi assays for CA125 were evaluated for analytical sensitivity, dilution linearity, imprecision, correlation and reference intervals. The maximum average deviation from target recoveries for dilution linearity studies ranged from 3.7% for the ADVIA Centaur to 18.2% for the IMMULITE 2000. Imprecision studies yielded total CVs of 2.0-8.3% at CA125 concentrations of 35 kU/L and 114 kU/L. Method comparison studies revealed good agreement with VITROS ECi comparison method with slopes ranging between 0.88 to 1.19 and correlation coefficients of >0.95. All methods show acceptable performance characteristics and generally compare well.
Type Text
Publisher Associated and Regional University Pathologists (ARUP) Institute for Clinical and Experimental Pathology
Subject CA125 assays
Subject MESH CA 125; Ovarian Neoplasms
Language eng
Bibliographic Citation uue_arup_000003_060217
Rights Management
Format Medium application/pdf
Format Extent 315,556 bytes
Identifier ir-main,100
ARK ark:/87278/s6bz6qp6
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 707105
Reference URL
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