Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C

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Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Other Author Antel, Jack P.; Yong, Voon Wee
Title Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C
Date 1992
Description THE PROLIFERATION RATES of gliomas may be modulated by the protein kinase C (PKC) signal transduction system. The present study was undertaken to further examine the role of PKC system in growth regulation of gliomas in vitro by measurement of PKC activity over various phases of tumor growth and by assessing its potential role as a signal transduction system induced by serum mitogens and the known glioma mitogens epidermal growth factor and fibroblast growth factor. All human glioma lines examined, and the rat glioma C6, displayed high PKC activity relative to nonmalignant glial cells, which correlated with their proliferation rates over their respective growth phase. Frozen surgical human malignant glioma specimens also displayed high PKC activity.
Type Text
Publisher Wolters Kluwer (LWW)
Volume 31
Issue 4
First Page 717
Last Page 724
Subject Protein kinase C; Brain neoplasms; Growth factor; Glioma; Phorbol ester
Subject LCSH Gliomas; Protein kinases; Tumor markers; Cancer -- Diagnosis; Brain -- Cancer
Language eng
Bibliographic Citation Couldwell, W. T., Antel, J. P., & Yong, V. W. (1992). Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C. Neurosurgery, 31(4), 717-24; discussion 724.
Rights Management (c) Wolters Kluwer (LWW)
Format Medium application/pdf
Format Extent 809,345 bytes
Identifier ir-main,12499
ARK ark:/87278/s6xh08sp
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 706971
Reference URL https://collections.lib.utah.edu/ark:/87278/s6xh08sp
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