Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Condie, Brian G.
Title Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.
Date 1994-07-28
Description The Hox genes encode transcription factors which mediate the formation of the mammalian body plan along the anteroposterior and appendicular axes. Paralogous Hox genes within the separate linkage groups are closely related with respect to DNA sequence and expression, suggesting that they could have at least partially redundant functions. We showed previously that mice homozygous for independent targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 had no defects in common. But our current analysis of double mutants has revealed strong, dosage-dependent interactions between these genes. We report here that in hoxd-3- homozygotes the first cervical vertebra, the atlas, is homeotically transformed to the adjacent anterior structure. Unexpectedly, in double mutants, rather than observing a more extensive homeotic transformation, the entire atlas is deleted. These observations are interpreted in terms of a model in which these Hox genes differentially regulate the proliferation rates of the appropriate sets of precursor cells.
Type Text
Publisher Nature Publishing Group
Volume 370
Issue 6487
First Page 304
Last Page 307
Subject Animals; Atlas; Homozygote; Mice; Models, Genetic
Subject MESH Cervical Vertebrae; Genes, Homeobox; Mutation
Language eng
Bibliographic Citation Nature. 1994 Jul 28;370(6487):304-7. Condie BG, Capecchi MR. Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Retrieved on November 2, 2006 from http://www.nature.com/nature/journal/v370/n6487/abs/370304a0.html.
Format Medium application/pdf
Identifier ir-main,557
ARK ark:/87278/s6960240
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 706501
Reference URL https://collections.lib.utah.edu/ark:/87278/s6960240
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