Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the cat

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Publication Type Journal Article
School or College College of Engineering
Department Bioengineering
Creator Horch, Kenneth W.
Other Author Lisney, S. J. W.
Title Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the cat
Date 1981
Description I. Micro-electrode recordings were made from normal and regenerating sural nerve fibres in cats. Increases in the excitability of the central terminals of these fibres after conditioning stimulation of other sural nerve fibres were taken as evidence for primary afferent depolarization. 2. At all recovery times studied the excitability changes seen were significantly less than those seen in control animals. Two factors contributed to the changes in primary afferent depolarization. First, the proportion of fibres that showed no evidence of primary afferent depolarization increased significantly. This proportion became smaller as recovery progressed. Secondly, where primary afferent depolarization was present, the magnitudes of the effects were slightly but significantly decreased compared with control values. 3. Excitability changes of the central terminals of sural nerve fibres were also measured after conditioning stimulation of the ipsilateral, unlesioned accessory sural nerve. One month after sural nerve transection there was a significant increase in the proportion of fibres showing no evidence of excitability changes following accessory sural nerve conditioning stimulation compared with control animals. Thus, the loss of primary afferent depolarization of regeneracing sural nerve fibres was neither simply a consequence of desynchronization of the volley of impulses entering the spinal cord after conditioning stimulation of other regenerating sural fibres, nor due to fewer fibres being activated during conditioning stimulation of the lesioned nerves. 4. A possible explanation of these results is that after peripheral nerve crush or transection the central terminals of the damaged fibres retract or atrophy. Then as regeneration of the nerve proceeds, the central terminals of the fibres re-form.
Type Text
Publisher Cambridge University Press
First Page 287
Last Page 299
Subject Micro-electrode recording; Nerve regeneration; Primary afferent depolarization
Subject MESH Sural Nerve; Afferent Pathways; Electrophysiology
Language eng
Bibliographic Citation Horch, K. W., & Lisney, S. J. W. (1981). Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the cat. Journal of Physiology, 313, 287-99.
Rights Management © Cambridge University Press
Format Medium application/pdf
Format Extent 845,970 Bytes
Identifier ir-main,3603
ARK ark:/87278/s6pz5tc4
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 706407
Reference URL https://collections.lib.utah.edu/ark:/87278/s6pz5tc4
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