Alternative splicing in the pore-forming region of shaker potassium channels

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Publication Type Journal Article
School or College College of Science
Department Biology
Creator Olivera, Baldomero M.
Other Author Kim, Marshall; Baro, Deborah J.; Lanning, Cathy C.; Doshi, Mehul; Farnham, Jeremy; Moskowitz, Howard S.; Peck, Jack H.; Harris-Warrick, Ronald M.
Title Alternative splicing in the pore-forming region of shaker potassium channels
Date 1997
Description We have cloned cDNAs for the shaker potassium channel gene from the spiny lobster Panulirus interruptus. As previously found in Drosophila, there is alternative splicing at the 59 and 39 ends of the coding region. However, in Panulirus shaker, alternative splicing also occurs within the pore-forming region of the protein. Three different splice variants were found within the P region, two of which bestow unique electrophysiological characteristics to channel function. Pore I and pore II variants differ in voltage dependence for activation, kinetics of inactivation, current rectification, and drug resistance.
Type Text
Publisher Society for Neuroscience
First Page 8213
Last Page 8224
Subject Panulirus interruptus; Conotoxins; Shaker; Stomatogastric ganglion; Pore-forming region; Alternative splicing
Subject LCSH Potassium channels; Ion channels; Neurotoxic agents; Drosophila -- Genetics
Language eng
Bibliographic Citation Kim, M., Baro, D. J., Lanning, C. C., Doshi, M., Farnham, J., Moskowitz, H. S., Peck, J .H., Olivera, B. M., & Harris-Warrick, R. M. (1997). Alternative splicing in the pore-forming region of shaker potassium channels. Journal of Neuroscience, 17, 8213-24.
Rights Management (c) Society for Neuroscience http://www.jneurosci.org/
Format Medium application/pdf
Format Extent 587,802 bytes
Identifier ir-main,8368
ARK ark:/87278/s6d79vw2
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 705886
Reference URL https://collections.lib.utah.edu/ark:/87278/s6d79vw2
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