Diagnostic performance of phospholipid-specific assays for the evaluation of antiphospholipid syndrome

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Publication Type Journal Article
Department Pathology
Program ARUP Institute for Clinical and Experimental Pathology
Creator Jaskowski, Troy D.
Other Author Tebo, Anne E.; Phansalkar, Amit R.; Litwin, Christine M.; Branch, D. Ware; Hill, Harry R.
Title Diagnostic performance of phospholipid-specific assays for the evaluation of antiphospholipid syndrome
Date 2008-06-01
Description The diagnostic performance of commercially available nonstandard antiphospholipid (aPL) assays for the evaluation of antiphospholipid syndrome (APS) is unknown. In 62 patients with APS, 88 with recurrent pregnancy loss, 50 healthy blood donors, and 24 women with one or more successful pregnancies, we measured antiphosphatidic acid (aPA), antiphosphatidyl-choline (aPC), antiphosphatidylethanolamine (aPE), antiphosphatidylglycerol (aPG), antiphosphatidylinositol (aPI), and antiphosphatidyl-serine (aPS) IgG and IgM antibodies from 2 manufacturers. We computed the areas under the curve (AUC), sensitivities, specificities, positive and negative predictive values, and 95% confidence intervals to assess diagnostic performance. The AUC analyses of the IgM assays demonstrated significant differences (P < .01) for all markers except aPC, whereas the IgG markers showed comparable performance for most assays with the exception of aPE (P < .01) and aPS (P = .02) antibodies. Overall, the combined sensitivity of the aPL assays differed significantly between manufacturers and did not improve the diagnostic yield for APS.
Type Text
Publisher American Society for Clinical Pathology
Journal Title American Journal of Clinical Pathology
Volume 129
Issue 6
First Page 870
Last Page 875
DOI 10.1309/6MPULFBL24FM9B50
citatation_issn 0002-9173
Subject APS; Phospholipid-specific assays; Diagnostic performance
Subject LCSH Antiphospholipid syndrome; Antiphospholipid syndrome -- Diagnosis
Language eng
Bibliographic Citation Tebo, A. E., Jaskowski, T. D., Phansalkar, A. R., Litwin, C. M., Branch, D. W., & Hill, H. R. (2008). Diagnostic performance of phospholipid-specific assays for the evaluation of antiphospholipid syndrome. American Journal of Clinical Pathology, 129(6), 870-5.
Rights Management ©1996-2010 American Society for Clinical Pathology and ©1996-2010 ASCP Press. http://dx.doi.org/10.1309/6MPULFBL24FM9B50
Format Medium application/pdf
Format Extent 353,600 bytes
Identifier ir-main,11439
ARK ark:/87278/s6h99ppx
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 705833
Reference URL https://collections.lib.utah.edu/ark:/87278/s6h99ppx
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