Development and evaluation of a anesthesia drug display

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Publication Type Journal Article
School or College School of Medicine; College of Education
Department Internal Medicine; Anesthesiology; Biomedical Informatics; Educational Psychology; Psychiatry
Creator Drews, Frank; Westenskow, Dwayne R.; Agutter, James A.; Strayer, David Lee
Other Author Syroid, N; Albert, R; Bermudez, J. C; Prenzel, H; Loeb, R; Weinger, M.
Title Development and evaluation of a anesthesia drug display
Date 2002-03
Description BACKGROUND: Usable real-time displays of intravenous anesthetic concentrations and effects could significantly enhance intraoperative clinical decision-making. Pharmacokinetic models are available to estimate past, present, and future drug effect-site concentrations, and pharmacodynamic models are available to predict the drug's associated physiologic effects. METHODS: An interdisciplinary research team (bioengineering, architecture, anesthesiology, computer engineering, and cognitive psychology) developed a graphic display that presents the real-time effect-site concentrations, normalized to the drugs' EC(95), of intravenous drugs. Graphical metaphors were created to show the drugs' pharmacodynamics. To evaluate the effect of the display on the management of total intravenous anesthesia, 15 anesthesiologists participated in a computer-based simulation study. The participants cared for patients during two experimental conditions: with and without the drug display. RESULTS: With the drug display, clinicians administered more bolus doses of remifentanil during anesthesia maintenance. There was a significantly lower variation in the predicted effect-site concentrations for remifentanil and propofol, and effect-site concentrations were maintained closer to the drugs' EC(95). There was no significant difference in the simulated patient heart rate and blood pressure with respect to experimental condition. The perceived performance for the participants was increased with the drug display, whereas mental demand, effort, and frustration level were reduced. In a post-simulation questionnaire, participants rated the display to be a useful addition to anesthesia monitoring. CONCLUSIONS: The drug display altered simulated clinical practice. These results, which will inform the next iteration of designs and evaluations, suggest promise for this approach to drug data visualization.
Type Text
Publisher Wolters Kluwer (LWW)
First Page 556
Last Page 574
Subject Blood Pressure; Computer Graphics; Patient Simulation
Subject MESH Anesthesia, Intravenous; Data Display
Language eng
Bibliographic Citation Syroid, N., Agutter, J., Drews, F., Westenskow, D., Bermudez, J., Albert, R., Strayer, D., Prenzel, H., Loeb, R., & Weinger, M. (2002). Development and evaluation of a graphical anesthesia drug display. Anesthesiology, 96, 556-74.
Rights Management (c) Wolters Kluwer (LWW)
Format Medium application/pdf
Format Extent 269,603 bytes
Identifier ir-main,2050
ARK ark:/87278/s6s18kzm
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 705769
Reference URL https://collections.lib.utah.edu/ark:/87278/s6s18kzm
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