Serial salivary estriol to detect an increased risk of preterm birth.

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Publication Type Journal Article
School or College School of Medicine
Department Pediatrics; Obstetrics & Gynecology
Creator Varner, Michael W.
Other Author Heine, R. Phillip; McGregor, James A.; Goodwin, T. Murphy; Artal, Raul; Hayashi, Robert H.; Robertson, Patricia A.
Title Serial salivary estriol to detect an increased risk of preterm birth.
Date 2000-10
Description OBJECTIVE: To evaluate serial measurements of salivary estriol (E3) to detect increased risk of spontaneous preterm labor and preterm birth. METHODS: A masked, prospective, multicenter trial of 956 women with singleton pregnancies was completed at eight United States medical centers. Saliva was collected weekly, beginning at the 22nd week of gestation until birth, and tested for unconjugated E3 by enzyme-linked immunosorbent assay. Women were separated into high-risk and low-risk groups using the Creasy scoring system. RESULTS: A single, positive (at or above 2.1 ng/mL) salivary E3 test predicted an increased risk of spontaneous preterm labor and delivery in the total population (relative risk [RR] 4.0, P <.005), in the low-risk population (RR 4.0, P < or =.05), and in the high-risk population (RR 3.4, P =.05). Two consecutive positive tests significantly increased the RR in all study groups, with a dramatic improvement in test specificity and positive predictive value but only a modest decrease in sensitivity. In women who presented with symptomatic preterm labor, salivary E3 identified 61% of those who delivered within 2 weeks, using a threshold of 1.4 ng/mL. CONCLUSION: Elevated salivary E3 is associated with increased risk of preterm birth in asymptomatic women and symptomatic women who present for evaluation of preterm labor
Type Text
Publisher Lippincott, Williams & Wilkins
Volume 96
Issue 4
First Page 490
Last Page 497
Subject Estriol; Preterm Birth; Spontaneous Preterm Labor
Subject MESH Pregnancy; Biological Markers; Estriol
Language eng
Bibliographic Citation Heine RP, McGregor JA, Goodwin TM, Artal R, Hayashi RH, Robertson PA, Varner MW. Serial salivary estriol to detect an increased risk of preterm birth. Obstet Gynecol. 2000 Oct;96(4):490-7. Retrieved on April 20. 2007 from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Display&DB=pubmed
Rights Management Copyright © Wolters Kluwer, Obstetrics and Gynecology, 96, 490-7, 2000
Format Medium application/pdf
Identifier ir-main,956
ARK ark:/87278/s6zw24b2
Setname ir_uspace
ID 705722
Reference URL https://collections.lib.utah.edu/ark:/87278/s6zw24b2
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