Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor.

Update item information
Publication Type Journal Article
School or College School of Medicine
Department Pediatrics; Obstetrics & Gynecology
Creator Varner, Michael W.
Other Author dudley, Donald J.; Hunter, Cheri; Mitchell, Murray D.
Title Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor.
Date 1996-01
Description OBJECTIVE: To determine whether elevated concentrations of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in amniotic fluid (AF) are related to term and preterm labor. METHODS: Amniotic fluid was obtained from women from five different clinical situations: 1) term cesarean delivery, no labor (n = 29); 2) normal term labor, no infection (n = 36); 3) preterm labor, delivery more than 1 week from sampling, no infection (n = 19); 4) preterm labor, delivery within 1 week from sampling, no infection (n = 18); and 5) preterm chorioamnionitis (n = 8). Amniotic fluid was collected aseptically at the time of amniocentesis, amniotomy, or hysterotomy. Concentrations of MIP-1 alpha were determined by enzyme-linked immunosorbent assay. Statistical analysis was by Wilcoxon rank-sum test, Kruskal-Wallis test, and unpaired t test. RESULTS: Women in normal term labor had significant elevations of AF MIP-1 alpha concentrations when compared with women at term undergoing repeat cesarean delivery (P < .001). In women with term gestation, AF MIP-1 alpha correlated well with cervical dilation (r2 = 0.479, P < .001). In women with preterm labor who later delivered within 1 week of presentation, AF MIP-1 alpha concentrations were higher than those from women who did not deliver within 1 week. Women who presented with clinically evident chorioamnionitis had the highest concentrations of AF MIP-1 alpha (P = .001). CONCLUSION: Women in labor have significantly elevated AF concentrations of MIP-1 alpha, particularly if labor is associated with intrauterine infection. We suggest that MIP-1 alpha is involved in the physiology of normal labor and in the pathogenesis of infection-associated preterm labor.
Type Text
Publisher Lippincott, Williams & Wilkins
Volume 87
Issue 1
First Page 94
Last Page 98
Subject Amniotic Fluid; Macrophage Inflammatory Protein-1; Obstetric Labor, Premature
Subject MESH Amniotic Fluid; Chorioamnionitis; Cytokines; Macrophage Inflammatory Protein-1; Obstetric Labor, Premature
Language eng
Bibliographic Citation Dudley DJ, Hunter C, Mitchell MD, Varner MW. ElevObstet Gynecol. 1996 Jan;87(1):94-8.Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor. Retrieved on May 29th 2007 from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?orig_db=PubMed&db=PubMed&cmd=Search&term=87%5Bvolume%5D+AND+1%5Bissue%5D+AND+94%5Bpage%5D+AND+Varner+MW%5Bauthor%5D
Rights Management Copyright © Wolters Kluwer, Obstetrics and Gynecology, 87, 94-8, 1996
Format Medium application/pdf
Identifier ir-main,1596
ARK ark:/87278/s6w95tqx
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 705684
Reference URL https://collections.lib.utah.edu/ark:/87278/s6w95tqx
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