Role of light-emitting diodes for photodynamic therapy of brain tumors

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Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Schmidt, Meic H.
Other Author Bajic, Dawn M.; Reichert II, Kenneth W.; Meyer, Glenn A.; Whelan, Harry T.; Martin, Todd S.
Title Role of light-emitting diodes for photodynamic therapy of brain tumors
Date 1996
Description The development of more effective light sources for Photodynamic Therapy (PDT) of brain tumors would be of benefit for both research and clinical application. In this study, the use of light-emitting diode arrays for PDT of brain tumors with Photofrin® porfimer sodium was investigated. An inflatable balloon device with an LED tip was constructed. These light-emitting diodes (LED's) are based on the new semiconductor Aluminum Gallium Arseide (AlGaAs). They can emit broad spectrum red light a high power levels with a peak wavelength of 677 nm and a bandwidth of 25 nm. The balloon was inflated with 0.1% intralipid which served as a light scattering medium. Measurements of light flux at several points showed a high degree of light dispersion. The spectral emission of this probe was then compared to the absorption spectrum of Photofrin®. this analysis showed that of 27.5% of the LED light emission is absorbed by Photofrin® as compared to a 630 nm monochromatic laser light source. Thus, in order to achieve an energy light dose equivalent to a laser light source, the LED light output has to be increased by a factor of 3.63. This need for additional energy is the difference between a 60 nm and 677 nm absorption of Photofrin®. Using the LED probe and the Laser balloon adapter, a comparison of brainstem toxicity in canines was conducted. LED and laser light showed the same signs of toxicity as equivalent light energy and Photofrin® doses. the Maximal Tolerated Dose (MTD) was 1.6 mg/kg and 100 j/cm2 of light energy (laser or LED). In addition, LED light was able to decrease glioma cell growth in vitro by 50%. This study concludes that LED's are a suitable light source for PDT of brain tumors with Photofrin®.
Type Text
Publisher American Institute of Physics (AIP)
Volume 361
Issue 1
First Page 403
Last Page 412
DOI 10.1063/1.50077
citatation_issn 0094243X
Subject Aluminum Gallium Arsenide; Photodynamic therapy; Brain tumors; Photofrin
Subject LCSH Brain -- Tumors -- Therapy; Photochemotherapy; Light emitting diodes; Gliomas
Language eng
Conference Title Space technology and applications international forum: 1st conference on commercial development of space; 1st conference on next generation launch systems; 2nd spacecraft thermal control symposium; 13th symposium on space nuclear power and propulsion; 7; Albuquerque, New Mexico (USA)
Bibliographic Citation Schmidt, M. H., Bajic, D. M., Reichert II, K. W., Meyer, G. A., Whelan, H. T. & Martin, T. S. (1996). Role of light-emitting diodes for photodynamic therapy of brain tumors. Space Technology and Applications International Forum, 361(1), 403-12.
Rights Management (c)American Institute of Physics. The following article appeared in Schmidt, M. H., Bajic, D. M., Reichert II, K. W., Meyer, G. A., Whelan, H. T. & Martin, T. S., Space Technology and Applications International Forum, 361(1), 1996, and may be found at http://dx.doi.org/10.1063/1.50077
Format Medium application/pdf
Format Extent 1,757,413 bytes
Identifier ir-main,12844
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Date Created 2012-06-13
Date Modified 2021-05-06
ID 705574
Reference URL https://collections.lib.utah.edu/ark:/87278/s6bz6qhz
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