| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; Hillyard, David R. |
| Other Author |
Santos, Ameurfina D.; Imperial, Julita S.; Chaudhary, Tanuja; Beavis, Ronald C.; Chait, Brian T.; Hunsperger, John P.; Adams, Michael E. |
| Title |
Heterodimeric structure of the spider toxin ω-Agatoxin IA revealed by precursor analysis and mass spectrometry |
| Date |
1992 |
| Description |
We report the first molecular characterization of a precursor sequence for a small, Ca2+ channel blocking, peptide spider toxin, ω-agatoxin IA. By integrating information generated from a molecular genetic approach using agatoxin cDNAs with data provided from mass spectrometry of the mature toxin, we were able to deduce the likely mechanisms by which the toxin precursor peptide is processed to its mature heterodimeric form. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
267 |
| Issue |
29 |
| First Page |
20701 |
| Last Page |
20705 |
| Subject |
Spider toxin w-Aga-IA; Heterodimeric structure |
| Subject LCSH |
Poisonous spiders -- Venom |
| Language |
eng |
| Bibliographic Citation |
Santos, A. D., Imperial, J. S., Chaudhary, T., Beavis, R. C., Chait, B. T., Hunsperger, J. P., Oliveram B. M., Adams, M. E., & Hillyard, D. R. (1992). Heterodimeric structure of the spider toxin ω-Agatoxin IA revealed by precursor analysis and mass spectrometry, Journal of Biological Chemistry, 267(29), 20701-5. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
696,833 bytes |
| Identifier |
ir-main,8319 |
| ARK |
ark:/87278/s61n8jkn |
| Setname |
ir_uspace |
| ID |
705561 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s61n8jkn |
