Role of photodynamic therapy in posterior fossa brain tumors: a preclinical study in a canine glioma model

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Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Schmidt, Meic H.
Other Author Whelan, Harry T.; Segura, Annette D.; McAuliffe, Timothy L.; Bajic, Dawn M.; Murray, Kevin J.; Moulder, John E.; Strother, Douglas R.; Thomas, James P.; Meyer, Glenn A.
Title Role of photodynamic therapy in posterior fossa brain tumors: a preclinical study in a canine glioma model
Date 1993
Description Photodynamic therapy was studied in dogs with and without posterior fossa glioblastomas. This mode of therapy consisted of intravenous administration of Photofrin-II at doses ranging from 0.75 to 4 mg/kg 24 hours prior to laser light irradiation in the posterior fossa. Tissue levels of Photofrin-lI were four times greater in the tumor than in the surrounding normal brain. Irradiation was performed using 1 hour of 500 mW laser light at a wavelength of 630 nm delivered through a fiberoptic catheter directly into the tumor bed via a burr hole. All animals receiving a high dose (4 or 2 mg/kg) of Photofrin-II developed serious brain-stem neurotoxicity resulting in death or significant residual neurological deficits. A lower dose (0.75 mg/kg) of Photofrin-II produced tumor kill without significant permanent brain-stem toxicity in either the control animals or the animals with cerebellar brain tumors receiving photodynamic therapy.
Type Text
Publisher American Association of Neurological Surgeons (AANS)
Volume 79
Issue 4
First Page 562
Last Page 568
Subject Brain neoplasm; Posterior fossa; Photodynamic therapy; Glioblastomas; Dog; Photofrin-II; Canine glioma model
Subject LCSH Photochemotherapy; Brain -- Cancer -- Treatment; Brain -- Cancer -- Animal models
Language eng
Bibliographic Citation Whelan, H. T., Schmidt, M. H., Segura, A. D., McAuliffe, T. L., Bajic, D. M., Murray, K. J., Moulder, J. E., Strother, D. R., Thomas, J. P., & Meyer, G. A. (1993). Role of photodynamic therapy in posterior fossa brain tumors: a preclinical study in a canine glioma model. Journal of Neurosurgery, 79(4), 562-8.
Rights Management (c) American Association of Neurological Surgeons
Format Medium application/pdf
Format Extent 881,001 bytes
Identifier ir-main,12755
ARK ark:/87278/s62v30kh
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 705318
Reference URL https://collections.lib.utah.edu/ark:/87278/s62v30kh
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