Fgf8 is required for outgrowth and patterning of the limbs.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Neurobiology & Anatomy; Oncological Sciences; Human Genetics; Pediatrics; Biology
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Moon, Ann M.; Capecchi, Mario R.
Title Fgf8 is required for outgrowth and patterning of the limbs.
Date 2000-12-26
Description The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we report that conditional disruption of Fgf8 in the forelimb of developing mice bypasses embryonic lethality and reveals a requirement for Fgf8 in the formation of the stylopod, anterior zeugopod and autopod. Lack of Fgf8 in the apical ectodermal ridge (AER) alters expression of other Fgf genes, Shh and Bmp2.
Type Text
Publisher Nature Publishing Group
Volume 26
Issue 4
First Page 455
Last Page 459
Subject Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm
Subject MESH Extremities; Fibroblast Growth Factors; Trans-Activators; Transforming Growth Factor beta
Language eng
Bibliographic Citation Nat Genet. 2000 Dec;26(4):455-9. Moon AM, Capecchi MR. Fgf8 is required for outgrowth and patterning of the limbs. Retrieved on November 1 2006 from http://www.nature.com/ng/journal/v26/n4/abs/ng1200_455.html.
Rights Management copyright © 2000 Nature Publishing Group. All Rights Reserved.
Format Medium application/pdf
Identifier ir-main,522
ARK ark:/87278/s66t153f
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 705083
Reference URL https://collections.lib.utah.edu/ark:/87278/s66t153f
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