Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia

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Publication Type Journal Article
School or College College of Health
Department Nutrition
Creator Symons, John David
Other Author Zaid, Ussama B.; Athanassious, Christian N.; Mullick, Adam E.; Lentz, Steven R.; Rutledge, John C.
Title Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia
Date 2006
Description Elevation of plasma total homocysteine (tHcy) is associated with an increased risk of cardiovascular disease, but the underlying mechanisms are not well understood.1 Worldwide, the most common cause of mild hyperhomocysteinemia (HHcy) is deficiency of folate.2,3 Some4-8 but not all9,10 studies suggest that folate deficiency contributes to cardiovascular disease in a manner that is independent of its ability to elevate plasma tHcy.11 We have reported that HHcy evoked by folate depletion increases arterial permeability and stiffness in rats.12
Type Text
Publisher American Heart Association
Volume 26
Issue 4
First Page 814
Last Page 818
Subject Cystathionine B-synthase; Carotid artery; Aorta; Cardiovascular risk factors; Folate; Hyperhomocysteinemia; Arterial permeability; Arterial stiffness
Subject LCSH Cardiovascular system -- Diseases -- Risk factors; Folic acid deficiency
Language eng
Bibliographic Citation Symons, J. D., Zaid, U. B., Athanassious, C. N., Mullick, A. E., Lentz, S. R., & Rutledge J.C. (2006). Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4), 814-8.
Rights Management (c)American Heart Association http://www.ahajournals.org/
Format Medium application/pdf
Format Extent 353,523 bytes
Identifier ir-main,1579
ARK ark:/87278/s67d3ch7
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 704753
Reference URL https://collections.lib.utah.edu/ark:/87278/s67d3ch7
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