Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.

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Publication Type Journal Article
School or College School of Medicine; College of Science
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Manley, Nancy R.
Title Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.
Date 1998-03-01
Description The thymus, thyroid, and parathyroid glands in vertebrates develop from the pharyngeal region, with contributions both from pharyngeal endoderm and from neural crest cells in the pharyngeal arches. Hoxa3 mutant homozygotes have defects in the development of all three organs. Roles for the Hoxa3 paralogs, Hoxb3 and Hoxd3, were investigated by examining various mutant combinations. The thyroid defects seen in Hoxa3 single mutants are exacerbated in double mutants with either of its paralogs, although none of the double-mutant combinations resulted in thyroid agenesis. The results indicate that the primary role of these genes in thyroid development is their effect on the development and migration of the ultimobranchial bodies, which contribute the parafollicular or C-cells to the thyroid. Hoxb3, Hoxd3 double mutants show no obvious defects in the thymus or parathyroids. However, the removal of one functional copy of Hoxa3 from the Hoxb3, Hoxd3 double mutants (Hoxa3 +/-, Hoxb3-/-, Hoxd3-/-) results in the failure of the thymus and parathyroid glands to migrate to their normal positions in the throat. Very little is known about the molecular mechanisms used to mediate the movement of tissues during development. These results indicate that Hoxa3, Hoxb3, and Hoxd3 have highly overlapping functions in mediating the migration of pharyngeal organ primordia. In addition, Hoxa3 has a unique function with respect to its paralogs in thymus, parathyroid, and thyroid development. This unique function may be conferred by the expression of Hoxa3, but not Hoxb3 nor Hoxd3, in the pharyngeal pouch endoderm.
Type Text
Publisher Academic Press Ltd.
Volume 195
Issue 1
First Page 1
Last Page 15
Subject Animals, Newborn; Calcitonin; Ectoderm; Gene Dosage; Genotype; Mice, Mutant Strains; Phenotype
Subject MESH DNA-Binding Proteins; Genes, Homeobox; Homeodomain Proteins; Parathyroid Glands; Thymus Gland; Thyroid Gland; Xenopus Proteins
Language eng
Bibliographic Citation Dev Biol. 1998 Mar 1;195(1):1-15. Manley NR, Capecchi MR. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Retrieved on November 1 2006 from http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDG-45JK5PJ-10&_coverDate=03%2F01%2F1998&_alid=479382448&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6766&_sort=d&view=c&_acct=C000049956&_version=1&_urlVersion=0&_userid=990933&md5=6fb6b86a8952480833e0bf78299fd015.
Rights Management Copyright ? 1998 Academic Press. All rights reserved.
Format Medium application/pdf
ARK ark:/87278/s66w9vdg
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 704668
Reference URL https://collections.lib.utah.edu/ark:/87278/s66w9vdg
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