Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Chen, Feng
Title Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.
Date 1999-01
Description Although the role of Hox genes in patterning the mammalian body plan has been studied extensively during embryonic and fetal development, relatively little is known concerning Hox gene function in adult animals. Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous genes are required for mediating the expansion and/or differentiation of the mammary epithelium ductal system in response to pregnancy. Mothers with these three mutant genes cannot raise their own pups, but the pups can be rescued by fostering by wild-type mothers. Histologically, the mammary glands of the mutant mothers seem normal before pregnancy but do not develop properly in response to pregnancy and parturition. Hoxa9, Hoxb9, and Hoxd9 are expressed normally in adult mammary glands, suggesting a direct role for these genes in the development of mammary tissue after pregnancy. Because loss-of-function mutations in these Hox genes cause hypoplasia of the mammary gland after pregnancy, it may be productive to look for misexpression of these genes in mammary carcinomas.
Type Text
Publisher National Academy of Sciences of the United States of America.
Volume 96
Issue 2
First Page 541
Last Page 546
Subject Embryonic and Fetal Development; Gene Expression Regulation, Developmental; Genotype; Mice, Knockout
Subject MESH Genes, Homeobox; In Situ Hybridization; Mammary Glands, Animal; Mutation
Language eng
Bibliographic Citation Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):541-6: Chen F, Capecchi MR, Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Retrieved on September 15.2006 from http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9892669.
Rights Management Copyright 1966 National Academy of Sciences of the United States of America. All right Reserved
Format Medium application/pdf
Identifier ir-main,419
ARK ark:/87278/s6tm7vgf
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 704494
Reference URL https://collections.lib.utah.edu/ark:/87278/s6tm7vgf
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