Change in ventricular size and effect of ventricular catheter placement in pediatric patients with shunted hydrocephalus

Update item information
Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Kestle, John R. W.
Other Author Tuli, Sagun; O'Hayon, Bonnie; Drake, James; Clarke, Michael
Title Change in ventricular size and effect of ventricular catheter placement in pediatric patients with shunted hydrocephalus
Date 1999
Description OBJECTIVE: The multicenter, randomized pediatric cerebrospinal fluid shunt valve design trial found no difference in the rate of shunt failure between a standard valve, a siphon-reducing valve (Delta; Medtronic PS Medical, Goleta, CA), and a flow-limiting valve (Orbis Sigma; Cordis, Miami, FL); however, the valves were expected to have different effects on ultimate ventricular size. Also, the catheter position or local environment of the ventricular catheter tip might have affected shunt failure. Therefore, we performed a post hoc analysis to understand what factors, other than valve design, affected shunt failure and to identify strategies that might be developed to reduce shunt failure. METHODS: Ventricular size was measured at as many as six different intervals, using a modified Evans' ratio (with incorporation of the frontal and occipital dimensions), in 344 patients. Ventricular catheter location was defined as being in the frontal horn, occipital horn, body of the lateral ventricle, third ventricle, embedded in brain, or unknown. The ventricular catheter tip was described as surrounded by cerebrospinal fluid, touching brain, or surrounded by brain parenchyma within the ventricle (slit ventricle). Repeated measures analysis of variance for unbalanced data was used to analyze ventricular size, A Cox model (with incorporation of time-dependent covariates) was used to evaluate the contribution of age, etiology, shunt design, yentricular size, ventricular catheter location,and environment among the cases. RESULTS: Ventricular volume decreased in an exponential fashion, forming a plateau at 14 months, and was similar for the three valves (P= 0.4). Frontal and occipital ventricular catheter tip locations were associated with a reduced risk of shunt failure (hazard ratios, 0,60 [P=0.02] and 0.45 [P= 0.001], respectively). Ventricular catheter tips surrounded by cerebrospinal fluid or touching the brain were associated with a reduced risk of failure (hazard ratios, 0.21 and 0.33, respectively;P= 0.0001). Patients with myelomeningocele or large yentricles had increased risk of malfunction (hazard ratios, 1.78 [P= 0.006] and 2.33 [P=0.03], respectively).
Type Text
Publisher Wolters Kluwer (LWW)
Volume 45
Issue 6
First Page 1329
Last Page 1335
Subject Shunt failure; Valve design; Ventricular size; Ventricular catheter placement
Subject LCSH Cerebrospinal fluid shunts; Hydrocephalus in children
Language eng
Bibliographic Citation Tuli, S., O'Hayon, B., Drake, J., Clarke, M., & Kestle, J. R. W. (1999). Change in ventricular size and effect of ventricular catheter placement in pediatric patients with shunted hydrocephalus. Neurosurgery, 45(6), 1329-35.
Rights Management (c) Wolters Kluwer (LWW) http://lww.com
Format Medium application/pdf
Format Extent 1,000,113 bytes
Identifier ir-main,13176
ARK ark:/87278/s6kd2g7m
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 704435
Reference URL https://collections.lib.utah.edu/ark:/87278/s6kd2g7m
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