Comparison of hospitalization rates in patients with community-acquired pneumonia treated with telithromycin for 5 or 7 days or clarithromycin for 10 days.

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Publication Type Journal Article
School or College College of Pharmacy
Department Pharmacotherapy
Creator Asche, Carl V.
Other Author Tellier, Guy; Chang, Joanne R.; Lavin, Bruce; Stewart, John; Sullivan, Sean D.
Title Comparison of hospitalization rates in patients with community-acquired pneumonia treated with telithromycin for 5 or 7 days or clarithromycin for 10 days.
Date 2004-08-01
Description AIMS: To compare the impact on hospitalization rates and the clinical efficacy of oral telithromycin and clarithromycin treatment in patients with community-acquired pneumonia (CAP). METHODS: A total of 581 patients with CAP were enrolled in this randomized, double-blind, parallel group, multinational study, of whom 575 were evaluated for healthcare resource utilization from a payer perspective (intent to treat [ITT] population). Patients received telithromycin 800 mg once daily for 5 (n = 193) or 7 (n = 195)days, or clarithromycin 500 mg once daily for 10 days (n = 187). The primary efficacy endpoint was clinical outcome at test of cure (Days 17-24) in the per-protocol population. Frequency of CAP-related hospitalizations, physician visits/tests/procedures, and additional respiratory tract infection-related antibacterial use were compared by treatment group (ITT) up to late post- for clarithromycin vs dollars 37930 (difference: -26446; therapy (Days 31-36). Study investigators blinded to treatment assessed whether hospital admissions were CAP-related or not. CAP-related hospitalization costs (USdollars) for telithromycin and clarithromycin were compared. RESULTS: Clinical cure rates were similar in patients who received clarithromycin for 10 days and telithromycin for 5 or 7 days: 91.8% (134/146), 89.3% (142/159), and 88.8% (143/161), respectively, and both 5- and 7-day telithromycin were statistically equivalent to clarithromycin (difference: -2.5 and -3.0%, respectively; 95% CI: -9.7, 4.7 and -10.2, 4.3, respectively). There were 7 CAP-related hospital admissions among clarithromycin patients vs 3 (p = 0.283) and 1 (p = 0.021) admissions among 5- and 7-day telithromycin patients, respectively. The number of hospital days/100 patients was 40.1 for clarithromycin vs 17.1 and 7.2 for 5- and 7-day telithromycin, respectively. Projected hospitalization costs/100 patients were dollars 86205 95% CI: -66 654; 13 762) and dollars 16 091 (difference: -37 847; 95% CI: -77953; 2259) for 5- and 7-day telithromycin, respectively. CONCLUSIONS: Data from this study demonstrate that telithromycin 800 mg once daily for 5 or 7 days with fewer hospital days and potentially lower is an effective treatment for CAP,and that telithromycin treatment of CAP may be associated hospitalization costs than clarithromycin treatment.
Type Text
Publisher LibraPham
Volume 20
Issue 5
First Page 739
Last Page 747
Subject Administration, Orall; Treatment Outcome
Subject MESH Anti-Bacterial Agents; Clarithromycin; Community-Acquired Infections; Hospitalization; Ketolides; Macrolides; Pneumonia
Language eng
Bibliographic Citation Curr Med Res Opin. 2004 May;20(5):739-47. Tellier G, Chang JR, Asche CV, Lavin B, Stewart J, Sullivan SD. Comparison of hospitalization rates in patients with community-acquired pneumonia treated with telithromycin for 5 or 7 days or clarithromycin for 10 days. Retrieved April 10, 2007 http://www.ingentaconnect.com/content/libra/cmro/2004/00000020/00000005/art00022?token=004e1844455eeab5644a467b4d616d3f4e4b34496e586546244034427c6b67213b6b6770701d4d.
Rights Management Copyright © 2004 LibraPharm all rights reserve.
Format Medium application/pdf
Identifier ir-main,923
ARK ark:/87278/s6jq1jb6
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 704383
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jq1jb6
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