Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers

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Publication Type Journal Article
School or College School of Medicine
Department Psychiatry
Creator Sung, Younghoon; Renshaw, Perry Franklin
Other Author Kim, Seog Ju; Lyoo, In Kyoon; Hwang, Jaeuk; Chung, Ain; Kim, Jihyun; Kwon, Do-Hoon; Chang, Kee Hyun
Title Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers
Date 2006
Description Author's explored grey-matter density in 29 methamphetamine abusers and 20 healthy comparison subjects using voxel-based morphometry. Grey-matter density changes and performances on the Wisconsin Card Sorting test (WCST) were also compared between 11 short-term (<6 months) and 18 long-term (o6 months) abstinent methamphetamine abusers. Methamphetamine abusers had lower grey-matter density in the right middle frontal cortex (corrected p<0.05) and more total errors in the WCST (p<0.01) relative to healthy comparison subjects. Grey-matter density decrease in the right middle frontal cortex correlated with total errors in the WCST in methamphetamine abusers (r=x0.45). Long-term abstinent abusers had significantly less right middle frontal grey-matter density decrease (p<0.01) and total errors in the WCST (p<0.01) than short-term abstinent abusers, but more than the healthy comparison subjects. We report that methamphetamine abusers have prefrontal grey-matter deficit, which may, in part, recover with long-term abstinence.
Type Text
Publisher Cambridge University Press
Volume 9
Issue 2
First Page 221
Last Page 228
Language eng
Bibliographic Citation Kim, S. J., Lyoo, I. K., Hwang, J., Chung, A., Sung, Y. H., Kim, J., Kwon, D. H., Change, K. H., & Renshaw, P. F. (2006). Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers. International Journal of Neuropsychopharmacology, 9(2), 221-8.
Rights Management © Cambridge University Press http://www.cambridge.org/ Permission granted by Cambridge University Press for non-commercial, personal use only.
Format Medium application/pdf
Format Extent 138,778 bytes
Identifier ir-main,16828
ARK ark:/87278/s69p3jzh
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 704295
Reference URL https://collections.lib.utah.edu/ark:/87278/s69p3jzh