Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Cole, Justin; Ertoy, Dilek; Lin, Hsinchen; Sutliff, Roy L.; Ezan, Eric; Guyene, Tham T.; Corvol, Pierre; Bernstein, Kenneth E.
Title Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice
Date 2000-10-31
Description While nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin levels. (51)Cr labeling of red cells showed that the knockout mice have a normal total blood volume but a reduced red cell mass. ACE knockout mice, which lack tissue ACE, are anemic despite having normal renal function. These mice have increased plasma levels of the peptide acetyl-SDKP, a possible stem cell suppressor. However, they also show low plasma levels of angiotensin II. Infusion of angiotensin II for 2 weeks increased hematocrit to near normal levels. These data suggest that angiotensin II facilitates erythropoiesis, a conclusion with implications for the management of chronically ill patients on inhibitors of the renin-angiotensin system.
Type Text
Publisher American Society for Clinical Investigation, http://www.asci-jci.org/
Volume 106
Issue 11
First Page 1391
Last Page 1398
Subject ACE
Subject MESH Anemia; Angiotensin II; Blood Pressure; Erythrocyte Indices; Erythropoiesis; Genotype; Hematocrit; Kidney; Mice, Inbred Strains; Mice, Knockout; Peptidyl-Dipeptidase A; Systole
Language eng
Bibliographic Citation Cole, J., Ertoy, D., Lin, H., Sutliff, R. L., Ezan, E., Guyene, T. T., Capecchi, M. R., Corvol, P., & Bernstein, K.E. (2000). Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. Journal of Clinical Investigation, 106(11), 1391-8. Retrieved May 2, 2006, from http://www.jci.org/cgi/reprint/106/11/1391
Rights Management Copyright 2000 American Society for Clinical Investigation. Reproduction of material presented in the journal is governed by the fair use limitations of US copyright law (detailed at http://www.loc.gov/copyright/title17/). You need to request permission to reproduce material if the use is commercial or if you wish to make multiple copies other than for educational purposes (http://www.jci.org/terms.shtml).
Format Medium application/pdf
Format Extent 687,104 bytes
Identifier ir-main,94
ARK ark:/87278/s67p9gpr
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 703928
Reference URL https://collections.lib.utah.edu/ark:/87278/s67p9gpr
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