Passive transfer of adjuvant-induced arthritis into irradiated DA recipient rats.

Update item information
Publication Type Journal Article
School or College College of Health; School of Medicine
Department Pathology; Physical Therapy; Internal Medicine
Creator Cannon, Grant W.; Clayton, Frederic; Griffiths, Marie M.
Other Author Harper, D. Scott
Title Passive transfer of adjuvant-induced arthritis into irradiated DA recipient rats.
Date 1993
Description Adjuvant-induced arthritis (AIA) can be passively transferred in Dark Agouti (DA) rats by spleen and lymph node cells after culture with Concanavalin A (Con A). A model not requiring in vitro Con A expansion and activation would be important in investigations of anti-rheumatic drugs in AIA. A new model using irradiated recipients fills this need. Donor DA rats treated with 0.1 ml complete Freund's adjuvant (CFA) containing 7.5 mg M. butyricum/ml were sacrificed 11 days after CFA injection, donor spleen cells harvested, and donor spleen cells injected intravenously into recipient DA rats previously irradiated with 5 Gy. Recipient rats developed arthritis 4-14 days after spleen cell transfer. This model can now be used to further define the effects of anti-rheumatic drugs in the passive transfer of AIA by eliminating the need for the in vitro Con A-induced expansion and/or activation of donor cells.
Type Text
Publisher Harwood Academic Publishers
Volume 15
Issue 4
First Page 267
Last Page 274
Subject Cell Transplantation; Rats, Inbred Strains
Subject MESH Arthritis, Experimental; Freund's Adjuvant
Language eng
Bibliographic Citation Autoimmunity. 1993;15(4):267-74. Cannon GW, Harper DS, Clayton F, Griffiths MM. Passive transfer of adjuvant-induced arthritis into irradiated DA recipient rats.
Rights Management Copyright © 1994 Harwood Academic Publishers. All rights reserved.
Format Medium application/pdf
Identifier ir-main,817
ARK ark:/87278/s6h71039
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 703926
Reference URL https://collections.lib.utah.edu/ark:/87278/s6h71039
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