Radiographic features of tumefactive giant cavernous angiomas

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Publication Type Manuscript
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Other Author Kan, Peter; Tubay, Marc; Osborn, Anne; Blaser, Susan
Title Radiographic features of tumefactive giant cavernous angiomas
Date 2008
Description Giant cavernous angiomas (GCAs) are very rare, and imaging features of GCAs can be very different from those of typical cavernous angiomas (CAs), making them a diagnostic challenge. The purpose of the study was to evaluate the radiographic features of GCAs, with an emphasis on the differentiating features from neoplastic lesions. Methods. The neuroradiological findings of 18 patients who harbored a histologically verified GCA (CA of 4 cm or larger) were reviewed retrospectively. The magnetic resonance imaging (MRI) appearance, enhancement pattern, presence of edema or mass effect, size, and location of each lesion was recorded. When available, pertinent clinical information, including age, sex, and mode of presentation, was obtained. Findings. Seizures, neurologic deficits, hemorrhage, and hydrocephalus were the most common presenting symptoms. The lesions were hyperdense and nonenhancing on computed tomography with frequent calcifications. On MRI, the lesions most commonly had a multicystic appearance, representing blood of various ages, and multiple complete hemosiderin rings. GCAs can present in any location with associating edema and mass effect, giving them a tumefactive appearance. No developmental venous anomaly was observed with any lesion. Conclusions. Most GCAs in our series presented as multicystic lesions with complete hemosiderin rings on MRI, giving a "bubbles of blood" appearance. Although this characteristic feature is helpful in the diagnosis of many cases of GCAs, the correct diagnosis in the remaining cases may not be apparent until histopathological evaluation of the specimen is made.
Type Text
Publisher Springer
Volume 150
Issue 1
First Page 49
Last Page 55
Subject Cavernous angiomas; Cavernous malformations; Tumefactive
Subject LCSH Angiomas; Brain -- Tumors -- Diagnosis; Imaging systems in medicine
Language eng
Bibliographic Citation Kan, P., Tubay, M., Osborn, A., Blaser, S., & Couldwell, W. T. (2008). Radiographic features of tumefactive giant cavernous angiomas. Acta Neurochirurgica (Wien), 150(1), 49-55.
Rights Management (c) Springer (The original publication is available at
Format Medium application/pdf
Format Extent 1,647,716 bytes
Identifier ir-main,12655
ARK ark:/87278/s6cv51zd
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2013-03-07
ID 703663
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