Rapid clinical diagnostics assays using injection-molded planar waveguides

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Publication Type Journal Article
School or College College of Engineering
Department Bioengineering
Creator Christensen, Douglas A.; Herron, James N.
Other Author Wang, Hsu-Kun; Terry, Alan H.; Durtschi, Jacob D.; Tan, Lyndon; Astill, Mark E.; Smith, Richard S.
Title Rapid clinical diagnostics assays using injection-molded planar waveguides
Date 1998
Description The goal of our research program is to develop an evanescent wave immunoassay system that can be used in point-of-care and critical care settings. Several key attributes are required to accomplish this goal: (i) the assay system should be at least as sensitive as present day immunoassays; (ii) assay time should be 5 minutes or less; (iii) the assay protocol should be relatively simple; (iv) the sensor should be capable of performing more than one assay on a single specimen; (v) the assay system should be able to accommodate specimens such as serum, plasma and whole blood; and (vi) the sensor should be an inexpensive, disposable cartridge. Our laboratory has developed an injection-molded planar waveguide sensor that meets most, if not alt, of these attributes. This sensor has been evaluated in a number of different immunoassays for analytes such as bovine serum albumin, human chorionic gonadotrophin, creatine phosphokinase MB and cardiac troponin I.
Type Text
Publisher International Society for Optical Engineering (SPIE)
Volume 3259
First Page 54
Last Page 64
DOI 10.1117/12.307322
Subject Planar waveguides; Creatine phosphokinase MB (CK-MB); Cardiac troponin I (cTnl); Diagnostics; Evanescence; Fluorescence; Human chorionic gonadotropin (hCG)
Subject LCSH Immunoassay; Wave guides; Biosensors; Immunodiagnosis; Chorionic gonadotropins
Language eng
Bibliographic Citation Herron, J. N., Wang, H.-K., Terry, A. H., Durtschi, J. D., Tan, L., Astill, M. E., Smith, R. S., & Christensen, D. A. (1998). Rapid clinical diagnostics assays using injection-molded planar waveguides. Proceedings of SPIE - The International Society for Optical Engineering, 3259, 54-64.
Rights Management ¬©Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.307322
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Identifier ir-main,11667
ARK ark:/87278/s6jt07n5
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 703592
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jt07n5