Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Davis, Allan Peter; Witte, David P.; Hsieh-Li, Hslu M.; Potter S. Steven
Title Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.
Date 2003-09-02
Description Mice with targeted disruptions in Hox genes have been generated to evaluate the role of the Hox complex in determining the mammalian body plan. This complex of 38 genes encodes transcription factors that specify regional information along the embryonic axes. Early in vertebrate evolution an ancestral complex shared with invertebrates was duplicated twice to give rise to the four linkage groups (Hox A, B, C and D). As a consequence, corresponding genes on the separate linkage groups, called paralogues, are most closely related to each other. Based on sequence similarities, the Hox genes have been subdivided into 13 paralogous groups. The five most 5' groups (Hox 9-13) pattern the posterior region of the vertebrate embryo and the appendicular skeleton. Mice with individual mutations in the paralogous genes hoxa-11 and hoxd-11 have been described. By breeding these two strains together we have generated double mutants which have dramatic phenotypes not apparent in mice homozygous for the individual mutations. The radius and the ulna of the forelimb are almost entirely eliminated, the axial skeleton shows homeotic transformations, and there are severe kidney defects not present in either single mutant. The limb and axial phenotypes are quantitative: as more mutant alleles are added to the genotype, the phenotype becomes progressively more severe. The appendicular skeleton defects suggest that paralogous Hox genes function together to specify limb outgrowth and patterning along the proximodistal axis.
Type Text
Publisher Nature Publishing Group
Volume 375
Issue 6534
First Page 791
Last Page 795
Subject Alleles; Animals; Bone and Bones; Carpal Bones
Subject MESH Genes, Homeobox; Homeodomain Proteins; Radius; Ulna
Language eng
Bibliographic Citation Nature. 1995 Jun 29;375(6534):791-5. Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Retrieved on November 1 2006 from http://www.nature.com/nature/journal/v375/n6534/abs/375791a0.html.
Rights Management copyright © 1995 Nature Publishing Group. All Rights Reserved.
Format Medium application/pdf
Identifier ir-main,520
ARK ark:/87278/s6gb2n72
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 703524
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gb2n72