Retinal projections in tyrosinase-negative albino cats

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Publication Type Journal Article
School or College School of Medicine
Department Ophthalmology; Neurobiology & Anatomy
Creator Creel, Donnell J.; Leventhal, Audie G.
Other Author Hendrickson, Anita
Title Retinal projections in tyrosinase-negative albino cats
Date 1982-07
Description Retinal projections were examined in two tyrosinase-negative albino cats using autoradiographic techniques. Cats from this colony have pink eyes; their retinal pigment epithelium, ciliary body, and iris epithelium are completely devoid of melanin pigment. Test breeding for five generations indicates that these cats are true albinos (cc). The most striking feature of the albino cats' visual pathways was a reduction in ipsilateral input which was more severe than that reported for Siamese cats. The only evidence of ipsilateral input to the laminated dorsal lateral geniculate nucleus of the albino was a small lateral normal segment and a small projection to the lateral portion of lamina C1. Ipsilateral projections to the medial interlaminar nucleus, retinal recipient zone of the pulvinar complex, ventral lateral geniculate nucleus, superior colliculus, and pretectum also were reduced. Ipsilateral projections to the suprachiasmatic nucleus appeared to be normal in the albino cats studied. Our findings indicate that, compared to the normal cat as well as to the tyrosine-positive Siamese cat, the tyrosinase-negative albino has reduced ipsilateral retinal projections. The albino cat is a model system analogous to tyrosinase-negative albinism found in mammals.
Type Text
Publisher Society for Neuroscience
Volume 2
Issue 7
First Page 907
Last Page 911
Subject Cats; Albinism; Vision; Autoradiography; Retina
Subject MESH Cats; Albinism; Vision; Autoradiography
Language eng
Bibliographic Citation Creel D, Hendrickson AE, Leventhal AG. (1982). Retinal projections in tyrosinase-negative albino cats. J Neurosci, 2(7), 907-11.
Rights Management (c) Society for Neuroscience
Format Medium application/pdf
Identifier ir-main,2059
ARK ark:/87278/s6j399sz
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 703365
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