Microvascular complications of impaired glucose tolerance.

Update item information
Publication Type Journal Article
School or College School of Medicine
Department Pathology; Neurology
Creator Singleton, J. Robinson; Smith, A. Gordon
Other Author Russell, James W.; Feldman Eva L.
Title Microvascular complications of impaired glucose tolerance.
Date 2003-12-01
Description Impaired glucose tolerance (IGT) serves as a marker for the state of insulin resistance and predicts both large- and small-vessel vascular complications, independent of a patient's progression to diabetes. Patients with IGT are at significantly increased risk for death and morbidity due to myocardial infarction, stroke, and large-vessel occlusive disease. IGT is more predictive of cardiovascular morbidity than impaired fasting glucose, probably because it is a better surrogate for the state of insulin resistance. IGT is also independently associated with traditional microvascular complications of diabetes, including retinopathy, renal disease, and polyneuropathy, which are the topics of this review. Inhibition of nitric oxide-mediated vasodilation, endothelial injury due to increased release of free fatty acids and adipocytokines from adipocytes, and direct metabolic injury of endothelial and end-organ cells contribute to vascular complications. Early detection of IGT allows intensive diet and exercise modification, which has proven significantly more effective than drug therapy in normalizing postprandial glucose and inhibiting progression to diabetes. To what degree intervention will limit recognized complications is not known.
Type Text
Publisher American Diabetes Association
Volume 52
Issue 12
First Page 2867
Last Page 2873
Subject Microcirculation; Humans
Subject MESH Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Glucose Intolerance; Polyneuropathies
Language eng
Bibliographic Citation iabetes. 2003 Dec;52(12):2867-73. Singleton JR,Smith AG, Russell JW, Feldman EL. Microvascular complications of impaired glucose tolerance. Retrieved from on April 24, 2007 from http://diabetes.diabetesjournals.org/cgi/content/full/52/12/2867.
Rights Management Copyright © 2003 American Diabetes Association. All rights reserved.
Format Medium application/pdf
Identifier ir-main,992
ARK ark:/87278/s6nk3z6p
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 703218
Reference URL https://collections.lib.utah.edu/ark:/87278/s6nk3z6p
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