Does progesterone treatment influence risk factors for recurrent preterm delivery?

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Publication Type Journal Article
School or College School of Medicine
Department Pediatrics; Obstetrics & Gynecology
Creator Varner, Michael W.
Other Author Meis, Paul J.; Klebanoff, Mark; Dombrowski, Mitchell P.; Sibai, Baha M.; Leindecker, Sharon; Moawad, Atef H.; Northen, Allison; Iams, Jay D.; Caritis, Steve N.; O'Sullivan, Mary J.; Miodovnik, Menachem; Leveno Kenneth J.; Conway, Deborah; Wapner, Ronald J.; Carpenter, Marshall; Mercer, Brian; Ramin, Susan M.; Thorp, John M.; Peaceman, Alan M.; Gabbe, Steven
Title Does progesterone treatment influence risk factors for recurrent preterm delivery?
Date 2005-09
Description OBJECTIVE: To examine how demographic and pregnancy characteristics can affect the risk of recurrent preterm delivery and the how the effectiveness of progesterone treatment for prevention alters these relationships. METHODS: This was a secondary analysis of a randomized trial of 17alpha-hydroxyprogesterone caproate to prevent recurrent preterm delivery in women at risk. Associations of risk factors for preterm delivery (less than 37 completed weeks of gestation) were examined separately for the women in the 17alpha-hydroxyprogesterone caproate (n = 310) and placebo (n = 153) groups. RESULTS: Univariate analysis found that the number of previous preterm deliveries and whether the penultimate delivery was preterm were significant risk factors for preterm delivery in both the placebo and progesterone groups. High body mass index was protective of preterm birth in the placebo group. Multivariate analysis found progesterone treatment to cancel the risk of more than 1 previous preterm delivery, but not the risk associated with the penultimate pregnancy delivered preterm. Obesity was associated with lower risk for preterm delivery in the placebo group but not in the women treated with progesterone. CONCLUSION: The use of 17alpha-hydroxyprogesterone caproate in women with a previous preterm delivery reduces the overall risk of preterm delivery and changes the epidemiology of risk factors for recurrent preterm delivery. In particular, these data suggest that 17alpha-hydroxyprogesterone caproate reduces the risk of a history of more than 1 preterm delivery. LEVEL OF EVIDENCE: I.
Type Text
Publisher Lippincott, Williams & Wilkins
Volume 106
Issue 3
First Page 557
Last Page 561
Subject Preterm Delivery; Progesterone Treatment; Pregnancy; Risk Factors
Subject MESH Hydroxyprogesterones; Multivariate Analysis; Obstetric Labor, Premature; Risk Factors
Language eng
Bibliographic Citation Meis PJ, Klebanoff M, Dombrowski MP, Sibai BM, Leindecker S, Moawad AH, Northen A, Iams JD, Varner MW, Caritis SN, O'Sullivan MJ, Miodovnik M, Leveno KJ, Conway D, Wapner RJ, Carpenter M, Mercer B, Ramin SM, Thorp JM, Peaceman AM, Gabbe S. Does progesterone treatment influence risk factors for recurrent preterm delivery? Obstet Gynecol. 2005 Sep;106(3):557-61. Retrieved on April 30th, 2007 from
Rights Management Copyright © Wolters Kluwer, Obstetrics and Gynecology, 106, 557-61, 2005
Format Medium application/pdf
ARK ark:/87278/s6t731kj
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 703033
Reference URL
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