Cloning and sequence analysis of the major outer membrane protein genes of two Chlamydia psittaci strains

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Publication Type Journal Article
School or College School of Medicine
Department Ophthalmology
Creator Baehr, Wolfgang
Other Author Zhang, Y X; Morrison, S G; Caldwell, H D
Title Cloning and sequence analysis of the major outer membrane protein genes of two Chlamydia psittaci strains
Date 1989
Description We cloned and sequenced the gene encoding the major outer membrane protein (MOMP) of two Chlamydia psittaci strains, guinea pig inclusion conjunctivitis (GPIC) strain 1, and meningopneumonitis (Mn) strain Cal-10. Intraspecies alignment of the two C. psittaci MOMP genes revealed 80.6% similarity, and interspecies comparison of C. trachomatis and C. psittaci MOMP genes yielded about 68% similarity. As found previously for C. trachomatis MOMP sequences, stretches of predominantly conserved sequences of GPIC and Mn MOMPs were interrupted by four variable domains whose locations were identical to those of C. trachomatis MOMPs. Seven of eight cysteine residues were found at precisely the same positions in GPIC, Mn, and C. trachomatis MOMPs, emphasizing their importance in structure and function of the protein. Collectively, these results indicate that C. psittaci and C. trachomatis MOMP genes diverged from a common ancestor.
Type Text
Publisher American Society for Microbiology
Volume 57
Issue 5
First Page 1621
Last Page 1625
Subject Base Sequence; Cloning, Molecular; Amino Acid Sequence
Subject MESH Chlamydophila psittaci; Bacterial Outer Membrane Proteins
Language eng
Bibliographic Citation Zhang YX, Morrison SG, Caldwell HD, Baehr W. (1989). Cloning and sequence analysis of the major outer membrane protein genes of two Chlamydia psittaci strains. Infect Immun, 57(5), 1621-5
Rights Management (c)American Society for Microbiology
Format Medium application/pdf
Identifier ir-main,1712
ARK ark:/87278/s6cn7n1f
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 702929
Reference URL https://collections.lib.utah.edu/ark:/87278/s6cn7n1f
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