Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve

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Publication Type Journal Article
School or College School of Medicine
Department Ophthalmology; Bioengineering; Surgery; Physiology
Creator Normann, Richard A.; Branner, Almut
Other Author Stein, Richard B.; Fernandez, Eduardo; Aoyagi, Yoichiro
Title Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve
Date 2004
Description We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions of surrounding muscles. Treadmill walking was monitored and the animals showed no functional deficits as a result of implantation. In a different set of experiments, electrodes with lead wires were implanted for up to 7 mo and the animals were tested at 2-4 week intervals at which time stimulation thresholds and recorded sensory activity were monitored for every electrode. It was shown that surgical technique highly affected the long-term stimulation results. Results between measurement sessions were compared, and in the best case, the stimulation properties stabilized in 80% of the electrodes over the course of the experiment (162 days). The recorded sensory signals, however, were not stable over time. A histological analysis performed on all implanted tissues indicated that the morphology and fiber density of the nerve around the electrodes were normal.
Type Text
Publisher Institute of Electrical and Electronics Engineers (IEEE)
Volume 51
Issue 1
First Page 146
Last Page 157
Subject Cats; Microelectrodes; Prosthesis Implantation; Sciatic Nerve
Subject MESH Cats; Electric Stimulation; Prosthesis Implantation; Sciatic Nerve; Muscle, Skeletal
Language eng
Bibliographic Citation Branner A, Stein RB, Fernandez E, Aoyagi Y, Normann RA. (2004). Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve. IEEE Trans Biomed Eng, 51(1), 146-57
Rights Management © Institute of Electrical and Electronics Engineers (IEEE)
Format Medium application/pdf
Identifier ir-main,12729
ARK ark:/87278/s6r21jhr
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 702903
Reference URL https://collections.lib.utah.edu/ark:/87278/s6r21jhr
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