Cross-reactivity of three recombinant insulin analogs with five commercial insulin immunoassays

Update Item Information
Publication Type Journal Article
Department Pathology
Program ARUP Institute for Clinical and Experimental Pathology
Creator Owen, William E.; Roberts, William L.
Title Cross-reactivity of three recombinant insulin analogs with five commercial insulin immunoassays
Date 2004
Description Several new insulin analogs that are prepared with recombinant DNA technology are available for clinical use [for a recent review, see Ref. (1)]. These agents have altered pharmacokinetics compared with regular human insulin. Insulin aspart (Novo-LogTM; Novo Nordisk Pharmaceuticals) is homologous with regular human insulin except for a single substitution of aspartic acid for proline at position B28. This single substitution reduces the molecule's tendency to form hexamers. Therefore, insulin aspart is absorbed more rapidly after subcutaneous injection and has both a faster onset of action and a shorter duration of action than regular insulin. A second short-acting recombinant insulin is insulin lispro (Humalog®; Eli Lilly and Company), which is a human insulin analog created by reversing the amino acids at positions 28 (Pro to Lys) and 29 (Lys to Pro) of the B chain. It is absorbed more rapidly than regular human insulin when administered subcutaneously and has a shorter duration of action.
Type Text
Publisher American Association for Clinical Chemistry
Volume 50
Issue 1
First Page 257
Last Page 259
Subject Insulin analogs; Insulin immunoassays; Cross-reactivity
Subject LCSH Insulin -- Derivatives
Language eng
Bibliographic Citation Owen, W. E., & Roberts, W. L. (2004). Cross-reactivity of three recombinant insulin analogs with five commercial insulin immunoassays [3]. Clinical Chemistry, 50(1), 257-9.
Rights Management (c)American Association for Clinical Chemistry
Format Medium application/pdf
Format Extent 92,037 bytes
Identifier ir-main,11554
ARK ark:/87278/s68630kt
Setname ir_uspace
ID 702869
Reference URL https://collections.lib.utah.edu/ark:/87278/s68630kt
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