Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.; Tvrdik, Petr
Other Author Arenkiel, Benjamin R.; Gaufo, Gary O.
Title Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry.
Date 2004-07-04
Description Formation of neuronal circuits in the head requires the coordinated development of neurons within the central nervous system (CNS) and neural crest-derived peripheral target tissues. Hoxb1, which is expressed throughout rhombomere 4 (r4), has been shown to be required for the specification of facial branchiomotor neuron progenitors that are programmed to innervate the muscles of facial expression. In this study, we have uncovered additional roles for Hoxb1-expressing cells in the formation and maintenance of the VIIth cranial nerve circuitry. By conditionally deleting the Hoxb1 locus in neural crest, we demonstrate that Hoxb1 is also required in r4-derived neural crest to facilitate and maintain formation of the VIIth nerve circuitry. Genetic lineage analysis revealed that a significant population of r4-derived neural crest is fated to generate glia that myelinate the VIIth cranial nerve. Neural crest cultures show that the absence of Hoxb1 function does not appear to affect overall glial progenitor specification, suggesting that a later glial function is critical for maintenance of the VIIth nerve. Taken together, these results suggest that the molecular program governing the development and maintenance of the VIIth cranial nerve is dependent upon Hoxb1, both in the neural crest-derived glia and in the facial branchiomotor neurons.
Type Text
Publisher Cold Spring Harbor Lab Press
Volume 16
Issue 24
First Page 3223
Last Page 3235
Subject Rhombomere 4; Branchiomotor; Cranial Nerve
Subject MESH Gene Expression Regulation, Developmental; Motor Neurons; Peripheral Nervous System
Language eng
Bibliographic Citation Arenkiel BR, Tvrdik P, Gaufo GO, Capecchi MR. Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. Genes Dev. 2002 Dec 15;16(24):3223-35. Retrived on September 1, 2006 from http://www.genesdev.org/cgi/content/full/16/24/3223.
Rights Management Copyright 2004 Cold Spring Harbor Laboratory Press. All Rights Reserved.
Format Medium application/pdf
Identifier ir-main,88
ARK ark:/87278/s6514gb6
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 702748
Reference URL https://collections.lib.utah.edu/ark:/87278/s6514gb6
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