Retinal Nerve Fiber Layer Thickness Using Spectral-Domain Optical Coherence Tomography in Patients With No Light Perception Secondary to Optic Atrophy

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Title Retinal Nerve Fiber Layer Thickness Using Spectral-Domain Optical Coherence Tomography in Patients With No Light Perception Secondary to Optic Atrophy
Creator Sylvia L. Groth, BA, Andrew Harrison, MD, Alana L. Grajewski, MD, Michael S. Lee, MD
Affiliation Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota
Abstract Optical coherence tomography (OCT) provides useful structural information that can augment functional data. Newer spectral-domain technology provides faster and higher resolution images than time-domain machines. Although each measures the same structures, the values systematically differ. We evaluated eyes with longstanding no light perception (NLP) visual acuity secondary to optic atrophy using spectral-domain OCT to determine minimum retinal nerve fiber layer (RNFL) thickness. The authors conducted a retrospective, crosssectional chart review study to identify patients with NLP acuity for 8 months or more and having a good quality Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) to measure the RNFL thickness. An unpaired t test compared the eyes with a previously published data set measured with time-domain OCT. Eleven eyes from 10 patients were examined with the Spectralis OCT. The mean duration of documented NLP acuity was 3.72-1.20 years. The mean RNFL thickness was 34.18 - 2.66 mm (95% coincidence interval, 28.26 40.11 mm). Mean RNFL thickness was significantly thinner on this spectral-domain OCT than previously published values on time-domain OCT (34.18 vs 45.42 mm, P = 0.004). Using the Spectralis OCT, mean RNFL thickness for NLP eyes due to optic atrophy is 28-40 mm. This provides clinicians useful information when considering how aggressively to manage patients with optic nerve disease.
Subject Adult; Older people, 80 and over; Cross-Sectional Studies; Female; Humans; Light; Male; Middle Older people; Nerve Fibers; Optic Atrophy; Retinal Neurons; Retrospective Studies; Tomography, Optical Coherence; Visual Acuity
OCR Text Show
Date 2013-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6rf915w
Setname ehsl_novel_jno
ID 227376
Reference URL https://collections.lib.utah.edu/ark:/87278/s6rf915w