The Use of Acetazolamide During Pregnancy in Intracranial Hypertension Patients

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Title The Use of Acetazolamide During Pregnancy in Intracranial Hypertension Patients
Creator Falardeau, Julie; Lobb, Brenna M; Golden, Sara; Maxfield, Steven D; Tanne, Emanuel
Affiliation Department of Ophthalmology; Intracranial Hypertension Registry; and Intracranial Hypertension Research Foundation, Oregon Health and Science University, Portland, Oregon; and Dartmouth Medical School, Hanover, New Hampshire
Subject Acetazolamide; Adult; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, First; Pseudotumor Cerebri; Questionnaires; Treatment Outcome
Abstract Acetazolamide is the mainstay of medical therapy for idiopathic intracranial hypertension (IIH). Its use in pregnant women has not been recommended because of reported teratogenic effects in rodents and rabbits. However, the safety of acetazolamide use during human pregnancy remains unclear. We report the pregnancy and offspring outcomes in women with intracranial hypertension (IH) treated with acetazolamide during pregnancy. Data were collected through questionnaires sent to patients with IH and their physicians. The questionnaires focused on IH diagnosis, obstetric history and outcomes, and pediatric outcomes. A total of 101 women with IH were consented (total of 158 pregnancies) and acetazolamide usage before 13 weeks of gestation was reported in 50 pregnancies. The risk of spontaneous abortion was similar to the control group and no major complication was identified in the offspring of women treated with acetazolamide. There is no convincing evidence for an adverse effect for acetazolamide use in human pr nancy, even when prescribed prior to the 13th week of gestation. While the liberal use of acetazolamide should be avoided during pregnancy, this medication should remain a treatment option in pregnant women when clinically indicated.
OCR Text Show
Date 2013-03
Type Text
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6hx4jsx
Setname ehsl_novel_jno
Date Created 2014-03-24
Date Modified 2014-07-10
ID 227370
Reference URL
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