Acute Effects of Sildenafil (Viagra) on Blue-on-Yellow and White-on-White Humphrey Perimetry

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Title Journal of Neuro-Ophthalmology, December 2000, Volume 20, Issue 4
Date 2000-12
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6b029x6
Setname ehsl_novel_jno
ID 225293
Reference URL https://collections.lib.utah.edu/ark:/87278/s6b029x6

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Title Acute Effects of Sildenafil (Viagra) on Blue-on-Yellow and White-on-White Humphrey Perimetry
Creator McCulley, TJ; Lamm BL; Marmor, MF; Hoffman, KB; Luu, JK; Feuer, WJ
Affiliation Bascom Palmer Eye Institute, University of Miami, Florida, USA.
Abstract OBJECTIVE: To study the effects of sildenafil on blue-on-yellow and white-on-white Humphrey visual field (HVF). MATERIALS AND METHODS: Healthy subjects, ages 20 to 38 years, were prospectively randomized to active drug (n = 5) or placebo (n = 3) groups. Blue-on-yellow and white-on-white HVF testing was performed before and 1 hour after masked dosing of sildenafil 200 mg or placebo. Changes in mean deviation (MD) were compared between groups. RESULTS: Three of three placebo and four of five sildenafil subjects had no change on HVF. One of five sildenafil subjects had a decrease in MD of 17.9 dB and 4.7 dB on blue-on-yellow and white-on-white HVF testing, respectively. This subject reported more systemic side effects than other subjects. CONCLUSIONS: Sildenafil has no effect on HVF testing in most persons; however, sildenafil caused an acute abnormality of HVF testing in one subject, who experienced pronounced non-visual systemic symptoms; this effect was greater on blue-on-yellow than white-on-white HVF.
Subject 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors; Adult; Female; Humans; Male; Perimetry; Piperazines/pharmacology; Prospective Studies; Purines; Retina/drug effects; Sulfones; Visual Fields/drug effects
OCR Text Show
Format application/pdf
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Setname ehsl_novel_jno
ID 225272
Reference URL https://collections.lib.utah.edu/ark:/87278/s6b029x6/225272
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