Detection and analysis of soft nanoparticles by the resistive pulse method

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Publication Type dissertation
School or College College of Science
Department Chemistry
Author Holden, Deric Avery
Title Detection and analysis of soft nanoparticles by the resistive pulse method
Date 2012-08
Description Soft nanoparticles have become increasingly important to the scientific and medical communities particularly in drug delivery systems due to their ability to deliver drugs in a time-dependent or site-specific manner. However, much is left unexplored in their permeation and translocation through porous biological membranes, such as those found in the body. This dissertation presents investigations of the resistive-pulse detection and analysis of soft nanoparticles including microgels and liposomes, using conical nanopores embedded in glass membranes. This analysis provides a first look at the permeation and translocation of soft nanoparticles through a porous membrane. Chapter 1 overviews nanoparticles and their uses in the scientific and medical communities, as well as the resistive-pulse technique and the glass nanopore membrane. Chapter 2 describes investigations on the pressure dependent deformation and translocation of 570 nm radius pNIPAm-AAc microgels through small conical nanopores in glass membranes using the resistive-pulse technique. Translocation event rates, durations, and current pulse heights are found to be a function of the relative conductivities of the microgel and the electrolyte solution. Also, a statistical analysis technique is used to determine the probability of coincident events.
Type Text
Publisher University of Utah
Subject Soft nanoparticles; Resistive pulse; Microgels; Permeation; Translocation; Porous biological membranes
Subject LCSH Nanoparticles
Dissertation Institution University of Utah
Dissertation Name Doctor of Philosophy
Language eng
Rights Management Copyright © Deric Avery Holden 2012
Format Medium application/pdf
Format Extent 5,224,298 bytes
Identifier etd3/id/1855
Source Original in Marriott Library Special Collections, QD3.5 2012 .H65
ARK ark:/87278/s66m3nmn
Setname ir_etd
Date Created 2012-08-20
Date Modified 2021-05-06
ID 195543
Reference URL https://collections.lib.utah.edu/ark:/87278/s66m3nmn