Simulation of diffusion in three unique situations for the novel capsule drug ring

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Publication Type thesis
School or College College of Engineering
Department Mechanical Engineering
Author Welborn, Austin Ray
Title Simulation of diffusion in three unique situations for the novel capsule drug ring
Date 2010-08
Description This work reports the results of simulations of drug release from a capsule drug ring (CDR) and the diffusion of that drug throughout the eye. The capsule drug ring (CDR) was recently developed at the University of Utah and is designed to be implanted with an intraocular lens after a cataract surgery. The CDR contains the drug Avastin which targets the protein called VEGF to prevent it from building new blood vessels that contribute to macular degeneration. The capsule drug ring is designed to be placed in the lens capsule near the vitreous humor to allow the Avastin to travel across the vitreous humor to the retina at the back of the eye. As the design is new, and no similar devices have been tested or developed, no other attempts have been made to model this situation so there is no data/information available. Accordingly, this work reports on the modeling and simulation of the CDR drug release and the drug transport across the eye. This is the main objective of the work done in this research. Three unique situations were created using SolidWorks, and COMSOL was used to simulate Avastin transport inside the human eye.
Type Text
Publisher University of Utah
Subject Capsule drug ring; Bevacizumab; Avastin; Retinal degeneration; Macular degeneration; Drug release; Drug delivery systems
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Rights Management ©Austin Ray Welborn
Format Medium application/pdf
Format Extent 2,347,239 bytes
Source Original housed in Marriott Library Special Collections; QA3.5 2010 .W45
ARK ark:/87278/s68w3v0f
Setname ir_etd
Date Created 2012-04-23
Date Modified 2018-04-18
ID 194124
Reference URL https://collections.lib.utah.edu/ark:/87278/s68w3v0f