Molecular mechanisms underlying the inhibitory effect of uniaxial cyclic stretch on endothelial cell migration

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Publication Type thesis
School or College College of Engineering
Department Bioengineering
Author Sun, Luis Cheng
Title Molecular mechanisms underlying the inhibitory effect of uniaxial cyclic stretch on endothelial cell migration
Date 2010-08
Description Vascular endothelial cells in large arteries are constantly subjected to uniaxial cyclic stretch in vivo as a result of blood pressure's pulsatile nature. This thesis research aimed to understand the molecular mechanisms underlying the inhibitory effect of uniaxial cyclic stretch on endothelial cell migration in a wound healing scenario and with different wound directionalities. Our results showed that cyclic stretch decreased the migration speed in wounds with both long axes perpendicular and parallel to the stretch direction. This decrease in migration speed was significantly greater in perpendicular wounds than in parallel wounds, a finding that explains the potential importance of selective surgical incision directionalities to promote faster vascular wound healing.
Type Text
Publisher University of Utah
Subject Cell migration; Cyclic stretch; DPI; NAC; Endothelial cells; Morphology; Reactive oxygen species; Vascular endothelium; Healing
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Rights Management ©Luis Cheng Sun
Format Medium application/pdf
Format Extent 3,053,080 Bytes
Source Original in Marriott LIbrary Special Collections, QP6.5 2010 .S96
ARK ark:/87278/s6h70wc8
Setname ir_etd
Date Created 2012-04-23
Date Modified 2021-05-06
ID 193210
Reference URL https://collections.lib.utah.edu/ark:/87278/s6h70wc8
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