The Microdistribution and retention of plutonium two thirty-nine on trabecular bone surfaces of the beagle : implications for the induction of osteosarcoma.

Update Item Information
Publication Type dissertation
School or College School of Medicine
Department Neurobiology & Anatomy
Author Wronski, Thomas Joseph.
Contributor Smith, James M. Dr.
Title The Microdistribution and retention of plutonium two thirty-nine on trabecular bone surfaces of the beagle : implications for the induction of osteosarcoma.
Date 1979-08
Description A study was initiated to investigate the relationship between the concentrations of 239Pu on trabecular bone surfaces and the rate of trabecular bone formation at specific skeletal sites of the beagle. The contribution of the above parameters to the incidence of 239Pu-induced osteosarcomas was also evaluated. Young adult beagles were administered single intravenous injections of ~0.016 um-Ci/kg of monomeric 239Pu-citrate. Beagles injected with citrate only served as controls. All animals were administered tetracycline derivatives intravenously in order to label activity forming bone surfaces. Two 239Pu-injected beagles and a control were sacrificed at each of seven different time periods from 7 to 365 day post-injection. Neutron-induced auto-radiographs were produced from thick bone sections subjected to a thermal neutron fluence of 10[16] n/cm2. The 239Pu concentration on trabecular bone surfaces was determined from microscopic counts of fission fragment tracks. The rate of trabecular bone formation was calculated from values for the surface/volume ratio of trabecular bone, the fractions of trabecular surface undergoing active bone formation, and the bone apposition rate. The lumbar vertebra, pelvis, and proximal humerus, each of which exhibits a high incidence of 239Pu-induced osteosarcomas, were found to have a high initial concentration of 239Pu on their trabecular surfaces (~7-8 pCi/cm2) and a relatively high rate of trabecular bone formation. The 239Pu concentration at these sites decreased to ~2-3 pCi/cm2 at the end of the first year. On the other had, the skeletal sites with a low tumor incidence, the proximal ulna and distal humerus, had a low initial concentration of 239Pu on their trabecular surfaces (~1-2 pCI/cm2) and a significantly lower rate of trabecular bone formation. The 239Pu concentration at these sites remained nearly constant throughout the experimental period. These data suggest that the micro-distribution and retention of 239Pu on the surfaces of trabecular bone are intimately related to the rate of trabecular bone turnover. Furthermore, it appears that a high initial deposition of 239Pu on trabecular surfaces and a high rate of trabecular bone turnover may contribute to the genesis of 239Pu-induced osteosarcomas. This study revealed that there are significant intraskeletal variations in the rate of trabecular bone formation, the rate of trabecular bone apposition, the initial deposition of 239Pu on trabecular surfaces, and the incidence of 239Pu-induced osteosarcomas. These variations appear to be related to the distribution of red and yellow marrow within the beagle skeleton, and may be the result of differences in the degree of vascularity of the two types of bone marrow.
Type Text
Publisher University of Utah
Subject Radiology; Isotopes; Radiactive Wastes
Subject MESH Bone and Bones; Osteosarcoma; Plutonium
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "The Microdistribution and retention of plutonium two thirty-nine on trabecular bone surfaces of the beagle : implications for the induction of osteosarcoma." Spencer S. Eccles Health Sciences Library. Print version of "The Microdistribution and retention of plutonium two thirty-nine on trabecular bone surfaces of the beagle : implications for the induction of osteosarcoma." available at J. Willard Marriott Library Special Collection. QP 6.5 1979 W76.
Rights Management © Thomas Joseph Wronski.
Format Medium application/pdf
Identifier us-etd2,100
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s6668tr8
Setname ir_etd
ID 192926
Reference URL https://collections.lib.utah.edu/ark:/87278/s6668tr8
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