A mathematical model of blood coagulation and platelet deposition under flow

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Publication Type dissertation
School or College College of Science
Department Mathematics
Author Gregg, Karin Leiderman
Title A mathematical model of blood coagulation and platelet deposition under flow
Date 2010-08
Description The body responds to vascular injury with two intertwined processes: platelet aggregation and coagulation. Platelet aggregation is a predominantly physical process, whereby platelets clump together, and coagulation is a cascade of biochemical enzyme reactions. Thrombin, the major product of coagulation, directly couples the biochemical system to platelet aggregation by activating platelets and by cleaving fibrinogen into fibrin monomers that polymerize to form a mesh that stabilizes platelet aggregates. Transport of coagulation proteins and platelets to and from an injury is controlled largely by the dynamics of the blood flow. To explore how blood flow affects the growth of thrombi and how the growing masses, in turn, feed back and affect the flow, we have developed the first spatial-temporal mathematical model of platelet aggregation and blood coagulation under flow that includes detailed descriptions of coagulation Biochemistry;, chemical activation and deposition of blood platelets, as well as the two-way interaction between the fluid dynamics and the growing platelet mass.
Type Text
Publisher University of Utah
Subject Mathematical model; Thrombosis
Subject LCSH Blood -- Coagulation -- Mathematical models; Blood platelets -- Aggregation -- Mathematical models
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Rights Management ©Karin Leiderman Gregg.
Format Medium application/pdf
Format Extent 6,687,173 bytes
Source Original in Marriott Library Special Collections, QA3.5 2010 .G74
ARK ark:/87278/s6571sh3
Setname ir_etd
Date Created 2012-04-23
Date Modified 2017-08-14
ID 192548
Reference URL https://collections.lib.utah.edu/ark:/87278/s6571sh3
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