Study of mouse brain phosphates after infection with Japanese B virus

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Publication Type thesis
School or College School of Medicine
Department Pathology
Author Higginbotham, Robert David
Title Study of mouse brain phosphates after infection with Japanese B virus
Date 1950
Description A method employing a single tube for the fractionation of mouse brain tissue was used to investigate the effects of the Japanese B virus on the phosphorylated compounds of this tissue. The inorganic, total acid-soluble, lipid, protein residue and total phosphorus fractions were studied. The MLD50 of the virus was determined at 24 hour intervals of the infection. A significant increase in the virus titre was found to be present 48 hours after inoculation. The maximum virus infectivity was found to occur prior to the onset of the encephalitis in the test animal. Although a slight increase in the inorganic phosphorus occurred with the advance of the virus incubation period, no striking changes in the relative concentration from the other phosphorus fractions was evident and no correlation between the phosphorus analyses and the virus infectivity could be made. It is suggest that a more adequate method employing radioactive phosphorus as an indicator of metabolic changes occurring in these fractions would yield some significant results.
Type Text
Publisher University of Utah
Subject Metabolism
Subject MESH Encephalitis Virus, Japanese; Phosphates
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "A Study of mouse brain phosphates after infection with Japanese B virus Spencer S. Eccles Health Sciences Library.
Rights Management © R. D. Higginbotham.
Format Medium application/pdf
Format Extent 4,151,832 bytes
Identifier undthes,4205
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Master File Extent 4,151,873 bytes
ARK ark:/87278/s6028tf0
Setname ir_etd
Date Created 2012-04-24
Date Modified 2012-04-26
ID 192008
Reference URL