Effect of immunization on defense mechanisms against infectious disease in irradiated animals

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Publication Type thesis
School or College School of Medicine
Department Biochemistry
Author Perkins, Eugene Hafen
Title Effect of immunization on defense mechanisms against infectious disease in irradiated animals
Date 1958-08
Description It was observed that a cellular infiltration of phagocytic cells induced in the peritoneum of x-irradiated mice by injection of a 0.1% glycogen saline solution enhanced the resistance of these animals to a later challenge of infection with K. pneumoniae. A single intraperitoneal injection of heterologous leukocytes (rat or rabbit) administered on any given day in the first postirradiation week failed to significantly reduce mortality of non-challenged irradiated mice. However animals which received two intraperitoneal injections of homologous phagocytic leukocytes at critical postirradiation periods exhibited reduced mortalities. Investigation carried on in vitro demonstrated that phagocytic cells of actively immunized animals had a enhanced ability to destroy or inhibit multiplication of viable organisms independent of demonstrable agglutinating antibody. Similarly in vivo experiments demonstrated that phagocytic cells of actively immunized animals had enhanced phagocytic function in that injections of these cells enhanced the resistance of irradiated mice to subsequent challenge with the homologous organisms whereas cell obtained from norm mice afforded no protection.
Type Text
Publisher University of Utah
Subject MESH Communicable Diseases; Defense Mechanisms
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "The effect of immunization on defense mechanisms against infectious disease in irradiated animals." Spencer S. Eccles Health Sciences Library.
Rights Management © Eugene Hafen Perkins.
Format Medium application/pdf
Format Extent 5,913,363 bytes
Identifier undthes,3834
Source Original University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Funding/Fellowship The research report herein was supported under contract AD 18(600)946 with th eU.S.A.F. School of Aviation Medicine, Randolph Field, Texas.
Master File Extent 5,913,405 bytes
ARK ark:/87278/s6js9sbt
Setname ir_etd
ID 191841
Reference URL https://collections.lib.utah.edu/ark:/87278/s6js9sbt
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