Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model

Update item information
Publication Type thesis
School or College School of Medicine
Department Pathology
Author Meola, Stacy D.
Title Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model
Date 2001-08
Description Anticoagulant and antiplatelet agents are currently being used clinically during episodes of unstable angina and non-Q-wave myocardial infarctions to stop thrombus formation to decrease morbidly and mortality. In vitro and ex vivo stent models were developed to assess thrombus formation, platelet incorporation and emboli development utilizing combinations of anticoagulant (heparin) and antiplatelet (Aggrastat ®) agents. The ex vivo model assessed thrombus and emboli formation in an ovine shunt model for nine drug combinations using gravimetric analysis and an unique light scattering microemboli detector (LSMS) to assess emboli in flowing blood. The in vitro model compared five therapy relationships using a one-pass bovine blood model using gravimetric analysis, radio-labeled platelets, and the LSMD. The results confirm that a combination therapy utilizing an anticoagulant and antiplatelet drug therapy the total thrombus weight and emboli produced can be decreased as compared to using an anticoagulant alone.
Type Text
Publisher University of Utah
Subject Heparin; Thrombus
Subject MESH Anticoagulants; Drug Therapy; Splints
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model." Spencer S. Eccles Health Sciences Library. Print version of "Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model." available at J. Willard Marriott Library Special Collection. RC39.5 2001 .M46.
Rights Management © Stacy D. Meola.
Format Medium application/pdf
Format Extent 2,099,496 bytes
Identifier undthes,5235
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 2,099,534 bytes
ARK ark:/87278/s61z469h
Setname ir_etd
Date Created 2012-04-24
Date Modified 2012-04-24
ID 191814
Reference URL https://collections.lib.utah.edu/ark:/87278/s61z469h