Biosynthesis of marine peptide natural products

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Publication Type thesis
School or College College of Pharmacy
Department Medicinal Chemistry
Author Nelson, James Thomas
Title Biosynthesis of marine peptide natural products
Date 2006-12
Description Saframycin-like ecteinascidins and patellamides are two groups of cytotoxic marine peptide natural products with potential application as anticancer therapeutics. The biosynthesis of the saframycins occurs through nonribosomal peptide synthesis and we show that the biosynthesis of the patellamides utilizes ribosomal peptide synthesis. This thesis contains investigations and insights into these biosynthetic systems and reports the successful heterologous production of patellamide A.
Type Text
Publisher University of Utah
Subject Pharmacokinetics; Chemical Synthesis
Subject MESH Antineoplastic Agents; Marine Toxins
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Biosynthesis of marine peptide natural products Spencer S. Eccles Health Sciences Library.
Rights Management © James Thomas Nelson.
Format Medium application/pdf
Format Extent 1,589,051 bytes
Identifier undthes,3930
Source Original University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Master File Extent 1,589,088 bytes
ARK ark:/87278/s6kd20tf
Setname ir_etd
ID 191717
Reference URL https://collections.lib.utah.edu/ark:/87278/s6kd20tf
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