Role of physical and chemical properties on gas transfer and blood compatibility of urethane membranes

Update item information
Publication Type dissertation
School or College School of Medicine
Department Biomedical Engineering
Author Knight, Patricia Marie
Title Role of physical and chemical properties on gas transfer and blood compatibility of urethane membranes
Date 1983-03
Description A major limitation to long-term blood oxygenation is damage to blood elements. Interposition of a membrane between the gas and blood phases has helped but the thrombogenicity of the membrane material still limits the long-term use of blood oxygenators. This can result in microemboli, local thrombosis, degradation of gas transfer or the loss of certain blood elements such as platelets. Some copolyurethanes have been reported to have improved blood compatibility. This study was undertaken to explore the use of these new material for blood oxygenation. This involved the determination of the gas permeability coefficients of the copolyurethane materials. Also, the effects of molecular structure and fabrication variables on the gas permeability coefficients were studied. From these studies, it became apparent that to provide adequate gas transfrer, the copolyurethanes would have to be fabricated very thin or microporous. Thus, porous copolyurethane films were cast onto porous supports and their gas fluxes and surface compatibility assessed with flowing blood in a system simulating and artificial lung. Comparisons were made with presently used membrane materials including silicone rubber, Goretex® and Celgard®. The gas transfer of the porous copolyether urethane membranes was found to depend on the substrate used and the polymer coating thickness. When the thickness of the polymer coating was kept in the 3 to 5 µm range, gas transfer was adequate for blood oxygenation. The copolyurethane membrances were observed to have good blood compatibility as oxygenator membranes in that they absorbed fewer blood elements and had very few clots compared to the other material tested. This may be related to the finding that these materials absorbed more albumin and less fibrinogen than the other materials.
Type Text
Publisher University of Utah
Subject Thrombogenicity; Cell Adhesion
Subject MESH Membranes, Artificial; Oxygenators, Membrane; Polyurethanes; Respiratory Transport
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "The role of physical and chemical properties on gas transfer and blood compatibility of urethane membranes." Spencer S. Eccles Health Sciences Library. Print version of "The role of physical and chemical properties on gas transfer and blood compatibility of urethane membranes." available at J. Willard Marriott Library Special Collection. QP 6.5 1983 K57.
Rights Management © Patricia Marie Knight.
Format Medium application/pdf
Format Extent 3,472,423 bytes
Identifier undthes,4628
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 3,472,506 bytes
ARK ark:/87278/s6cj8gbr
Setname ir_etd
Date Created 2012-04-24
Date Modified 2021-07-14
ID 191556
Reference URL https://collections.lib.utah.edu/ark:/87278/s6cj8gbr
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