Plasma membrane cholesterol homeostasis

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Publication Type dissertation
School or College School of Medicine
Department Human Genetics
Author Mallampalli, Monica
Title Plasma membrane cholesterol homeostasis
Date 2002-08
Description The level of free intracellular cholesterol is strictly controlled by a wellcharacterized set of homeostatic mechanisms. In contrast, the mechanisms that control the intracellular distribution of sterols between various membranes within the cell are poorly understood. The majority (>95%) of cellular cholesterol resides in the plasma membrane and in endocytic vesicles derived from the plasma membrane. Here I describe my work designed to elucidate the mechanisms by which this intracellular distribution is developed and maintained. In Chapter 1, I review what is known about the intracellular distribution of cholesterol and the transport mechanisms that maintain these distributions. In Chapter 2, I describe the characterization of NPC fibroblasts, which have a defect in the transport of LDL-derived cholesterol from the endo/lysosomal compartment to the plasma membrane. I also describe the development and use of an assay to measure this transport process <italic>in vitro
Type Text
Publisher University of Utah
Subject Physiology
Subject MESH Homeostasis; Cholesterol; Cell Membrane
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Plasma membrane cholesterol homeostasis." Spencer S. Eccles Health Sciences Library. Print version of "Plasma membrane cholesterol homeostasis." available at J. Willard Marriott Library Special Collection. QP6.5 2002 .M34.
Rights Management © Monica Mallampalli.
Format Medium application/pdf
Format Extent 4,943,204 bytes
Identifier undthes,4835
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship Department of Human Genetics at University of Utah.
Master File Extent 4,943,244 bytes
ARK ark:/87278/s6mk6fq1
Setname ir_etd
Date Created 2012-04-24
Date Modified 2021-05-06
ID 191260
Reference URL
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