Intracellular acid-base metabolism of rat smooth and skeletal muscle

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Publication Type thesis
School or College College of Pharmacy
Department Pharmacology & Toxicology
Author Elsmore, Trudy Ann
Title Intracellular acid-base metabolism of rat smooth and skeletal muscle
Date 1965-08
Description The intracellular pH (pHi) of smooth muscles has been studied for the first time. In addition, the relationship between intracellular pH and a variety of extracellular acid-base distortions has been compared in smooth and skeletal muscle. Extracellular acid-base distortions were produced in vivo in animals mechanically respired with either 1) atmospheres containing CO2 (respiratory distortions) or 2) room air after the injection of either NaHCO3 or NH4Ci solution (metabolic distortions). The following general relationships between pHi and pHe were found to apply to both smooth and skeletal muscle. 1) Intracellular pH decreases in metabolic or respiratory acidosis, and increases in metabolic or respiratory alkalosis. However, there are certain limits of pHe within which intracellular pH changes very little when extracellular pH is varied by either respiratory or metabolic means. 2) Intracellular pH is related to extracellular CO2 tension, pH and bicarbonate ([HCO3-])oncentration, but, at any given pHe, CO2 tension has a greater influence on p1^ than does [HCO3-]. The following discrete differences between smooth and skeletal muscle pHj in relation to the extracellular acid-base status were observed. 1) Intracellular pH of smqoth muscle is higher than that of skeletal muscle. 2) Smooth muscle pHi is stable over a smaller range of pHe than is skeletal muscle pHj. 3) Smooth muscle pHi is more sensitive than is skeletal muscle pHi to extracellular metabolic acidosis. 4) Smooth muscle pHi is affected less than is skeletal muscle pH^ by respiratory distortions of pHe. These results, and other known differences between smooth and skeletal muscle, suggest that smooth muscle pHi regulation is related to extracellular HCO3- as well as to H+ ion extrusion, while skeletal muscle pHi regulation is primarily a function of H^ extrusion.
Type Text
Publisher University of Utah
Subject Muscles - Metabolism; Muscles - Cytology
Subject MESH Muscles; Metabolism; Cytology
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Intracellular acid-base metabolism of rat smooth and skeletal muscle Spencer S. Eccles Health Sciences Library.
Rights Management © Trudy Ann Elsmore.
Format Medium application/pdf
Format Extent 1,036,653 bytes
Identifier undthes,4226
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Master File Extent 1,036,683 bytes
ARK ark:/87278/s62v2hvx
Setname ir_etd
Date Created 2012-04-24
Date Modified 2018-01-10
ID 190644
Reference URL https://collections.lib.utah.edu/ark:/87278/s62v2hvx
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