Structure of the small ribosomal subunit

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Publication Type dissertation
School or College School of Medicine
Department Biochemistry
Author Clemons, William Melvon
Contributor Gowda, Krishne; Black, Shaun; Zweib, Christian; Ramakrishnan, Venki
Title Structure of the small ribosomal subunit
Date 2000-12
Description The ribosome is one of the most important components of the cell. It is solely responsible for protein synthesis in every organism. Aside from its biological interest, the ribosome is potent target for many antibiotics used in medicine and biology. Biochemists have studied the ribosome for decades, yet the details of ribosome mechanism have always been elusive. The introductory first chapter gives a history of ribosome research with an emphasis on structural studies. Protein crystallography was used to determine the atomic structure of the small ribosomal subunit. In the process of doing this two intermediate stages were reached. The first of the stages was the atomic structure of ribosomal protein S 15 from Bacillus stearothermophilus and is detailed in Chapter 2. The second stage was the medium resolution structure of the entire small subunit from Thermus thermophilus and is described in Chapter 3. These results facilitated the 3Å structure of the whole of the structure of the small subunit detailed in Chapter 4. The aim of this thesis is to provide the reader with a clear understanding of the interest in ribosome structural work along with explaining the functional insights gleaned from the structure of the small ribosomal subunit.
Type Text
Publisher University of Utah
Subject Genetics; Nucleotides
Subject MESH Ribosomes; Proteins; RNA; Adenosine
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "The structure of the small ribosomal subunit." Spencer S. Eccles Health Sciences Library. Print version of "The structure of the small ribosomal subunit." available at J. Willard Marriott Library Special Collection. QH9.7 2000 .C58.
Rights Management © William Melvon Clemons, Junior.
Format Medium application/pdf
Format Extent 7,642,272 bytes
Identifier undthes,4629
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship Biological Training Grant from the University of Utah and a NOH predoctoral fellowship
Master File Extent 7,642,308 bytes
ARK ark:/87278/s6tm7cw1
Setname ir_etd
Date Created 2012-04-24
Date Modified 2021-05-06
ID 190584
Reference URL
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