The role of angiotensinogen in the pathophysiology of hypertension

Update item information
Publication Type dissertation
School or College School of Medicine
Department Human Genetics
Author Gociman, Barbu Razvan
Title The role of angiotensinogen in the pathophysiology of hypertension
Date 2004-12
Description Essential hypertension is an important cause of human cardiovascular morbidity and mortality in most developed countries. Analysis of hypertensive siblings has revealed significant genetic linkage and alleilic association between angiotensinogen, the precursor of angiotensin II, and essential hypertension. Angiotensinogen is one of the components of the renin-angiotensin system that plays a central role in blood pressure regulation. Beside the circulating system, multiple tissue renin-angiotensin system including in arterial wall, heart, brain, and kidney have been described. Transgenic models confirmed a direct, causal relationship between increased angiotensinogen gene copy number and increased arterial pressure. Nevertheless, the site of action of angiotensinogen overexpression on increased pressure remains only speculative. We proposed to identify the role that individual renin-angiotensin systems have on the hypertensive phenotype by creating animal models with altered tissue-specific angiotensinogen expression. Furthermore, for a better understanding of the renal system, we will investigate the regulation and its interaction with other systems involved in blood pressure homeostatsis.
Type Text
Publisher University of Utah
Subject Physiopathology; Kallikrein
Subject MESH Hypertension; Angiotensins
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "The role of angiotensinogen in the pathophysiology of hypertension." Spencer S. Eccles Health Sciences Library. Print version of "The role of angiotensinogen in the pathophysiology of hypertension." available at J. Willard Marriott Library Special Collection. RC39.5 2004 .G63
Rights Management © Barbu Razvan Gociman.
Format Medium application/pdf
Format Extent 2,265,839 bytes
Identifier undthes,5476
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 2,265,866 bytes
ARK ark:/87278/s68054cg
Setname ir_etd
Date Created 2012-04-24
Date Modified 2012-04-24
ID 190542
Reference URL https://collections.lib.utah.edu/ark:/87278/s68054cg