Walsh & Hoyt: Treatment

Update Item Information
Identifier wh_ch60_p3501_2
Title Walsh & Hoyt: Treatment
Creator Laura J. Balcer, MD
Affiliation Professor, Department of Neurology, NYU Langone
Subject Demyelinating Diseases; Neuromyelitis Optica; Devic's Disease; Treatment
Description There is no proven effective treatment for neuromyelitis optica. Supportive care is crucial to ensure survival in patients with severe myelitis. The use of high-dose IV corticosteroids may lessen the severity of the attack and increase the speed of recovery of both visual and motor function. Some patients, however, may become steroid-dependent and experience relapses of symptoms with tapering of dosage. Frohman et al. reported the case of a 15-year-old boy who developed typical neuromyelitis optica when he was 12 years old. His vision recovered, but he experienced recurrent attacks of bilateral, simultaneous optic neuritis over the next 3 years and became steroid-dependent. Administration of IV-Ig allowed discontinuation of steroids without further ophthalmologic or neurologic deterioration or recurrent disease. Plasma exchange was also associated with improvement in a small case series (10 patients). Interferons and immunosuppressants, including azathioprine, have been tried, but prospective data from controlled studies demonstrating efficacy are lacking. Given the occurrence of spontaneous improvement in neuromyelitis optica, randomized controlled trials of therapies are needed to establish treatment recommendations.
Date 2005
Language eng
Format application/pdf
Type Text
Source Walsh and Hoyt's Clinical Neuro-Ophthalmology, 6th Edition
Relation is Part of Walsh and Hoyt's Clinical Neuro-Ophthalmology Walsh and Hoyt's Clinical Neuro-Ophthalmology
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Wolters Kluwer Health, Philadelphia
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management Copyright 2005. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6jh6vqp
Setname ehsl_novel_whts
ID 186111
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jh6vqp
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