Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling and Subretinal Fluid Accumulation Acutely and More Severe Thinning Chronically (.pdf)

Non-arteritic ischemic optic neuropathy (AION) is the most common acute optic neuropathy in those older than 501-2 and is associated with post-ischemic inflammation and oligodendrocyte dysfunction and degeneration. Diabetes mellitus (DM) is one of the most common vascular risk factors and leads to vascular changes, inflammation, and neuron loss. We studied the contribution of elevated glucose in experimental AION and assessed retinal and inflammatory changes.